Ubiquitin and ubiquitin-like molecules in DNA double strand break repair

Both environmental and endogenous factors induce various forms of DNA damage. DNA double strand break (DSB) is the most deleterious DNA lesion. The swift initiation of a complexed network of interconnected pathways to repair the DNA lesion is essential for cell survival. In the past years, the roles...

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Detalles Bibliográficos
Autores principales: Yu, Jia, Qin, Bo, Lou, Zhenkun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7014694/
https://www.ncbi.nlm.nih.gov/pubmed/32071713
http://dx.doi.org/10.1186/s13578-020-0380-1
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author Yu, Jia
Qin, Bo
Lou, Zhenkun
author_facet Yu, Jia
Qin, Bo
Lou, Zhenkun
author_sort Yu, Jia
collection PubMed
description Both environmental and endogenous factors induce various forms of DNA damage. DNA double strand break (DSB) is the most deleterious DNA lesion. The swift initiation of a complexed network of interconnected pathways to repair the DNA lesion is essential for cell survival. In the past years, the roles of ubiquitin and ubiquitin-like proteins in DNA damage response and DNA repair has been explored. These findings help us better understand the complicated mechanism of DSB signaling pathways.
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spelling pubmed-70146942020-02-18 Ubiquitin and ubiquitin-like molecules in DNA double strand break repair Yu, Jia Qin, Bo Lou, Zhenkun Cell Biosci Review Both environmental and endogenous factors induce various forms of DNA damage. DNA double strand break (DSB) is the most deleterious DNA lesion. The swift initiation of a complexed network of interconnected pathways to repair the DNA lesion is essential for cell survival. In the past years, the roles of ubiquitin and ubiquitin-like proteins in DNA damage response and DNA repair has been explored. These findings help us better understand the complicated mechanism of DSB signaling pathways. BioMed Central 2020-02-11 /pmc/articles/PMC7014694/ /pubmed/32071713 http://dx.doi.org/10.1186/s13578-020-0380-1 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Yu, Jia
Qin, Bo
Lou, Zhenkun
Ubiquitin and ubiquitin-like molecules in DNA double strand break repair
title Ubiquitin and ubiquitin-like molecules in DNA double strand break repair
title_full Ubiquitin and ubiquitin-like molecules in DNA double strand break repair
title_fullStr Ubiquitin and ubiquitin-like molecules in DNA double strand break repair
title_full_unstemmed Ubiquitin and ubiquitin-like molecules in DNA double strand break repair
title_short Ubiquitin and ubiquitin-like molecules in DNA double strand break repair
title_sort ubiquitin and ubiquitin-like molecules in dna double strand break repair
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7014694/
https://www.ncbi.nlm.nih.gov/pubmed/32071713
http://dx.doi.org/10.1186/s13578-020-0380-1
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