Mechanism of increased risk of insulin resistance in aging skeletal muscle

As age increases, the risk of developing type 2 diabetes increases, which is associated with senile skeletal muscle dysfunction. During skeletal muscle aging, mitochondrial dysfunction, intramyocellular lipid accumulation, increased inflammation, oxidative stress, modified activity of insulin sensit...

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Autores principales: Shou, Jian, Chen, Pei-Jie, Xiao, Wei-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7014712/
https://www.ncbi.nlm.nih.gov/pubmed/32082422
http://dx.doi.org/10.1186/s13098-020-0523-x
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author Shou, Jian
Chen, Pei-Jie
Xiao, Wei-Hua
author_facet Shou, Jian
Chen, Pei-Jie
Xiao, Wei-Hua
author_sort Shou, Jian
collection PubMed
description As age increases, the risk of developing type 2 diabetes increases, which is associated with senile skeletal muscle dysfunction. During skeletal muscle aging, mitochondrial dysfunction, intramyocellular lipid accumulation, increased inflammation, oxidative stress, modified activity of insulin sensitivity regulatory enzymes, endoplasmic reticulum stress, decreased autophagy, sarcopenia and over-activated renin-angiotensin system may occur. These changes can impair skeletal muscle insulin sensitivity and increase the risk of insulin resistance and type 2 diabetes during skeletal muscle aging. This review of the mechanism of the increased risk of insulin resistance during skeletal muscle aging will provide a more comprehensive explanation for the increased incidence of type 2 diabetes in elderly individuals, and will also provide a more comprehensive perspective for the prevention and treatment of type 2 diabetes in elderly populations. [Image: see text]
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spelling pubmed-70147122020-02-20 Mechanism of increased risk of insulin resistance in aging skeletal muscle Shou, Jian Chen, Pei-Jie Xiao, Wei-Hua Diabetol Metab Syndr Review As age increases, the risk of developing type 2 diabetes increases, which is associated with senile skeletal muscle dysfunction. During skeletal muscle aging, mitochondrial dysfunction, intramyocellular lipid accumulation, increased inflammation, oxidative stress, modified activity of insulin sensitivity regulatory enzymes, endoplasmic reticulum stress, decreased autophagy, sarcopenia and over-activated renin-angiotensin system may occur. These changes can impair skeletal muscle insulin sensitivity and increase the risk of insulin resistance and type 2 diabetes during skeletal muscle aging. This review of the mechanism of the increased risk of insulin resistance during skeletal muscle aging will provide a more comprehensive explanation for the increased incidence of type 2 diabetes in elderly individuals, and will also provide a more comprehensive perspective for the prevention and treatment of type 2 diabetes in elderly populations. [Image: see text] BioMed Central 2020-02-11 /pmc/articles/PMC7014712/ /pubmed/32082422 http://dx.doi.org/10.1186/s13098-020-0523-x Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Shou, Jian
Chen, Pei-Jie
Xiao, Wei-Hua
Mechanism of increased risk of insulin resistance in aging skeletal muscle
title Mechanism of increased risk of insulin resistance in aging skeletal muscle
title_full Mechanism of increased risk of insulin resistance in aging skeletal muscle
title_fullStr Mechanism of increased risk of insulin resistance in aging skeletal muscle
title_full_unstemmed Mechanism of increased risk of insulin resistance in aging skeletal muscle
title_short Mechanism of increased risk of insulin resistance in aging skeletal muscle
title_sort mechanism of increased risk of insulin resistance in aging skeletal muscle
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7014712/
https://www.ncbi.nlm.nih.gov/pubmed/32082422
http://dx.doi.org/10.1186/s13098-020-0523-x
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