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Antivenin plants used for treatment of snakebites in Uganda: ethnobotanical reports and pharmacological evidences

Snakebite envenomation is a serious public health concern in rural areas of Uganda. Snakebites are poorly documented in Uganda because most occur in rural settings where traditional therapists end up being the first-line defense for treatment. Ethnobotanical surveys in Uganda have reported that some...

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Autores principales: Omara, Timothy, Kagoya, Sarah, Openy, Abraham, Omute, Tom, Ssebulime, Stephen, Kiplagat, Kibet Mohamed, Bongomin, Ocident
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7014759/
https://www.ncbi.nlm.nih.gov/pubmed/32071543
http://dx.doi.org/10.1186/s41182-019-0187-0
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author Omara, Timothy
Kagoya, Sarah
Openy, Abraham
Omute, Tom
Ssebulime, Stephen
Kiplagat, Kibet Mohamed
Bongomin, Ocident
author_facet Omara, Timothy
Kagoya, Sarah
Openy, Abraham
Omute, Tom
Ssebulime, Stephen
Kiplagat, Kibet Mohamed
Bongomin, Ocident
author_sort Omara, Timothy
collection PubMed
description Snakebite envenomation is a serious public health concern in rural areas of Uganda. Snakebites are poorly documented in Uganda because most occur in rural settings where traditional therapists end up being the first-line defense for treatment. Ethnobotanical surveys in Uganda have reported that some plants are used to antagonize the activity of various snake venoms. This review was sought to identify antivenin plants in Uganda and some pharmacological evidence supporting their use. A literature survey done in multidisciplinary databases revealed that 77 plant species belonging to 65 genera and 42 families are used for the treatment of snakebites in Uganda. The majority of these species belong to family Fabaceae (31%), Euphorbiaceae (14%), Asteraceae (12%), Amaryllidaceae (10%) and Solanaceae (10%). The main growth habit of the species is shrubs (41%), trees (33%) and herbs (18%). Antivenin extracts are usually prepared from roots (54%) and leaves (23%) through decoctions, infusions, powders, and juices, and are administered orally (67%) or applied topically (17%). The most frequently encountered species were Allium cepa, Carica papaya, Securidaca longipedunculata, Harrisonia abyssinica, and Nicotiana tabacum. Species with global reports of tested antivenom activity included Allium cepa, Allium sativum, Basella alba, Capparis tomentosa, Carica papaya, Cassia occidentalis, Jatropa carcus, Vernonia cinereal, Bidens pilosa, Hoslundia opposita, Maytensus senegalensis, Securinega virosa, and Solanum incanum. There is need to identify and evaluate the antivenom compounds in the claimed plants.
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spelling pubmed-70147592020-02-18 Antivenin plants used for treatment of snakebites in Uganda: ethnobotanical reports and pharmacological evidences Omara, Timothy Kagoya, Sarah Openy, Abraham Omute, Tom Ssebulime, Stephen Kiplagat, Kibet Mohamed Bongomin, Ocident Trop Med Health Review Snakebite envenomation is a serious public health concern in rural areas of Uganda. Snakebites are poorly documented in Uganda because most occur in rural settings where traditional therapists end up being the first-line defense for treatment. Ethnobotanical surveys in Uganda have reported that some plants are used to antagonize the activity of various snake venoms. This review was sought to identify antivenin plants in Uganda and some pharmacological evidence supporting their use. A literature survey done in multidisciplinary databases revealed that 77 plant species belonging to 65 genera and 42 families are used for the treatment of snakebites in Uganda. The majority of these species belong to family Fabaceae (31%), Euphorbiaceae (14%), Asteraceae (12%), Amaryllidaceae (10%) and Solanaceae (10%). The main growth habit of the species is shrubs (41%), trees (33%) and herbs (18%). Antivenin extracts are usually prepared from roots (54%) and leaves (23%) through decoctions, infusions, powders, and juices, and are administered orally (67%) or applied topically (17%). The most frequently encountered species were Allium cepa, Carica papaya, Securidaca longipedunculata, Harrisonia abyssinica, and Nicotiana tabacum. Species with global reports of tested antivenom activity included Allium cepa, Allium sativum, Basella alba, Capparis tomentosa, Carica papaya, Cassia occidentalis, Jatropa carcus, Vernonia cinereal, Bidens pilosa, Hoslundia opposita, Maytensus senegalensis, Securinega virosa, and Solanum incanum. There is need to identify and evaluate the antivenom compounds in the claimed plants. BioMed Central 2020-02-11 /pmc/articles/PMC7014759/ /pubmed/32071543 http://dx.doi.org/10.1186/s41182-019-0187-0 Text en © The Author(s) 2020 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Omara, Timothy
Kagoya, Sarah
Openy, Abraham
Omute, Tom
Ssebulime, Stephen
Kiplagat, Kibet Mohamed
Bongomin, Ocident
Antivenin plants used for treatment of snakebites in Uganda: ethnobotanical reports and pharmacological evidences
title Antivenin plants used for treatment of snakebites in Uganda: ethnobotanical reports and pharmacological evidences
title_full Antivenin plants used for treatment of snakebites in Uganda: ethnobotanical reports and pharmacological evidences
title_fullStr Antivenin plants used for treatment of snakebites in Uganda: ethnobotanical reports and pharmacological evidences
title_full_unstemmed Antivenin plants used for treatment of snakebites in Uganda: ethnobotanical reports and pharmacological evidences
title_short Antivenin plants used for treatment of snakebites in Uganda: ethnobotanical reports and pharmacological evidences
title_sort antivenin plants used for treatment of snakebites in uganda: ethnobotanical reports and pharmacological evidences
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7014759/
https://www.ncbi.nlm.nih.gov/pubmed/32071543
http://dx.doi.org/10.1186/s41182-019-0187-0
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