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Contribution of Phase Resetting to Adaptive Rhythm Control in Human Walking Based on the Phase Response Curves of a Neuromusculoskeletal Model

Humans walk adaptively in varying environments by manipulating their complicated and redundant musculoskeletal system. Although the central pattern generators in the spinal cord are largely responsible for adaptive walking through sensory-motor coordination, it remains unclear what neural mechanisms...

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Autores principales: Tamura, Daiki, Aoi, Shinya, Funato, Tetsuro, Fujiki, Soichiro, Senda, Kei, Tsuchiya, Kazuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7015040/
https://www.ncbi.nlm.nih.gov/pubmed/32116492
http://dx.doi.org/10.3389/fnins.2020.00017
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author Tamura, Daiki
Aoi, Shinya
Funato, Tetsuro
Fujiki, Soichiro
Senda, Kei
Tsuchiya, Kazuo
author_facet Tamura, Daiki
Aoi, Shinya
Funato, Tetsuro
Fujiki, Soichiro
Senda, Kei
Tsuchiya, Kazuo
author_sort Tamura, Daiki
collection PubMed
description Humans walk adaptively in varying environments by manipulating their complicated and redundant musculoskeletal system. Although the central pattern generators in the spinal cord are largely responsible for adaptive walking through sensory-motor coordination, it remains unclear what neural mechanisms determine walking adaptability. It has been reported that locomotor rhythm and phase are regulated by the production of phase shift and rhythm resetting (phase resetting) for periodic motor commands in response to sensory feedback and perturbation. While the phase resetting has been suggested to make a large contribution to adaptive walking, it has only been investigated based on fictive locomotion in decerebrate cats, and thus it remains unclear if human motor control has such a rhythm regulation mechanism during walking. In our previous work, we incorporated a phase resetting mechanism into a motor control model and demonstrated that it improves the stability and robustness of walking through forward dynamic simulations of a human musculoskeletal model. However, this did not necessarily verify that phase resetting plays a role in human motor control. In our other previous work, we used kinematic measurements of human walking to identify the phase response curve (PRC), which explains phase-dependent responses of a limit cycle oscillator to a perturbation. This revealed how human walking rhythm is regulated by perturbations. In this study, we integrated these two approaches using a physical model and identification of the PRC to examine the hypothesis that phase resetting plays a role in the control of walking rhythm in humans. More specifically, we calculated the PRC using our neuromusculoskeletal model in the same way as our previous human experiment. In particular, we compared the PRCs calculated from two different models with and without phase resetting while referring to the PRC for humans. As a result, although the PRC for the model without phase resetting did not show any characteristic shape, the PRC for the model with phase resetting showed a characteristic phase-dependent shape with trends similar to those of the PRC for humans. These results support our hypothesis and will improve our understanding of adaptive rhythm control in human walking.
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spelling pubmed-70150402020-02-28 Contribution of Phase Resetting to Adaptive Rhythm Control in Human Walking Based on the Phase Response Curves of a Neuromusculoskeletal Model Tamura, Daiki Aoi, Shinya Funato, Tetsuro Fujiki, Soichiro Senda, Kei Tsuchiya, Kazuo Front Neurosci Neuroscience Humans walk adaptively in varying environments by manipulating their complicated and redundant musculoskeletal system. Although the central pattern generators in the spinal cord are largely responsible for adaptive walking through sensory-motor coordination, it remains unclear what neural mechanisms determine walking adaptability. It has been reported that locomotor rhythm and phase are regulated by the production of phase shift and rhythm resetting (phase resetting) for periodic motor commands in response to sensory feedback and perturbation. While the phase resetting has been suggested to make a large contribution to adaptive walking, it has only been investigated based on fictive locomotion in decerebrate cats, and thus it remains unclear if human motor control has such a rhythm regulation mechanism during walking. In our previous work, we incorporated a phase resetting mechanism into a motor control model and demonstrated that it improves the stability and robustness of walking through forward dynamic simulations of a human musculoskeletal model. However, this did not necessarily verify that phase resetting plays a role in human motor control. In our other previous work, we used kinematic measurements of human walking to identify the phase response curve (PRC), which explains phase-dependent responses of a limit cycle oscillator to a perturbation. This revealed how human walking rhythm is regulated by perturbations. In this study, we integrated these two approaches using a physical model and identification of the PRC to examine the hypothesis that phase resetting plays a role in the control of walking rhythm in humans. More specifically, we calculated the PRC using our neuromusculoskeletal model in the same way as our previous human experiment. In particular, we compared the PRCs calculated from two different models with and without phase resetting while referring to the PRC for humans. As a result, although the PRC for the model without phase resetting did not show any characteristic shape, the PRC for the model with phase resetting showed a characteristic phase-dependent shape with trends similar to those of the PRC for humans. These results support our hypothesis and will improve our understanding of adaptive rhythm control in human walking. Frontiers Media S.A. 2020-02-05 /pmc/articles/PMC7015040/ /pubmed/32116492 http://dx.doi.org/10.3389/fnins.2020.00017 Text en Copyright © 2020 Tamura, Aoi, Funato, Fujiki, Senda and Tsuchiya. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Tamura, Daiki
Aoi, Shinya
Funato, Tetsuro
Fujiki, Soichiro
Senda, Kei
Tsuchiya, Kazuo
Contribution of Phase Resetting to Adaptive Rhythm Control in Human Walking Based on the Phase Response Curves of a Neuromusculoskeletal Model
title Contribution of Phase Resetting to Adaptive Rhythm Control in Human Walking Based on the Phase Response Curves of a Neuromusculoskeletal Model
title_full Contribution of Phase Resetting to Adaptive Rhythm Control in Human Walking Based on the Phase Response Curves of a Neuromusculoskeletal Model
title_fullStr Contribution of Phase Resetting to Adaptive Rhythm Control in Human Walking Based on the Phase Response Curves of a Neuromusculoskeletal Model
title_full_unstemmed Contribution of Phase Resetting to Adaptive Rhythm Control in Human Walking Based on the Phase Response Curves of a Neuromusculoskeletal Model
title_short Contribution of Phase Resetting to Adaptive Rhythm Control in Human Walking Based on the Phase Response Curves of a Neuromusculoskeletal Model
title_sort contribution of phase resetting to adaptive rhythm control in human walking based on the phase response curves of a neuromusculoskeletal model
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7015040/
https://www.ncbi.nlm.nih.gov/pubmed/32116492
http://dx.doi.org/10.3389/fnins.2020.00017
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