Derangements of amino acids in cachectic skeletal muscle are caused by mitochondrial dysfunction

BACKGROUND: Cachexia is the direct cause of at least 20% of cancer‐associated deaths. Muscle wasting in skeletal muscle results in weakness, immobility, and death secondary to impaired respiratory muscle function. Muscle proteins are massively degraded in cachexia; nevertheless, the molecular mechan...

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Detalles Bibliográficos
Autores principales: Kunzke, Thomas, Buck, Achim, Prade, Verena M., Feuchtinger, Annette, Prokopchuk, Olga, Martignoni, Marc E., Heisz, Simone, Hauner, Hans, Janssen, Klaus‐Peter, Walch, Axel, Aichler, Michaela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7015243/
https://www.ncbi.nlm.nih.gov/pubmed/31965747
http://dx.doi.org/10.1002/jcsm.12498

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