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Advancing human health risk assessment
The current/traditional human health risk assessment paradigm is challenged by recent scientific and technical advances, and ethical demands. The current approach is considered too resource intensive, is not always reliable, can raise issues of reproducibility, is mostly animal based and does not ne...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7015480/ https://www.ncbi.nlm.nih.gov/pubmed/32626449 http://dx.doi.org/10.2903/j.efsa.2019.e170712 |
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author | Lanzoni, Anna Castoldi, Anna F Kass, George EN Terron, Andrea De Seze, Guilhem Bal‐Price, Anna Bois, Frédéric Y Delclos, K Barry Doerge, Daniel R Fritsche, Ellen Halldorsson, Thorhallur Kolossa‐Gehring, Marike Hougaard Bennekou, Susanne Koning, Frits Lampen, Alfonso Leist, Marcel Mantus, Ellen Rousselle, Christophe Siegrist, Michael Steinberg, Pablo Tritscher, Angelika Van de Water, Bob Vineis, Paolo Walker, Nigel Wallace, Heather Whelan, Maurice Younes, Maged |
author_facet | Lanzoni, Anna Castoldi, Anna F Kass, George EN Terron, Andrea De Seze, Guilhem Bal‐Price, Anna Bois, Frédéric Y Delclos, K Barry Doerge, Daniel R Fritsche, Ellen Halldorsson, Thorhallur Kolossa‐Gehring, Marike Hougaard Bennekou, Susanne Koning, Frits Lampen, Alfonso Leist, Marcel Mantus, Ellen Rousselle, Christophe Siegrist, Michael Steinberg, Pablo Tritscher, Angelika Van de Water, Bob Vineis, Paolo Walker, Nigel Wallace, Heather Whelan, Maurice Younes, Maged |
author_sort | Lanzoni, Anna |
collection | PubMed |
description | The current/traditional human health risk assessment paradigm is challenged by recent scientific and technical advances, and ethical demands. The current approach is considered too resource intensive, is not always reliable, can raise issues of reproducibility, is mostly animal based and does not necessarily provide an understanding of the underlying mechanisms of toxicity. From an ethical and scientific viewpoint, a paradigm shift is required to deliver testing strategies that enable reliable, animal‐free hazard and risk assessments, which are based on a mechanistic understanding of chemical toxicity and make use of exposure science and epidemiological data. This shift will require a new philosophy, new data, multidisciplinary expertise and more flexible regulations. Re‐engineering of available data is also deemed necessary as data should be accessible, readable, interpretable and usable. Dedicated training to build the capacity in terms of expertise is necessary, together with practical resources allocated to education. The dialogue between risk assessors, risk managers, academia and stakeholders should be promoted further to understand scientific and societal needs. Genuine interest in taking risk assessment forward should drive the change and should be supported by flexible funding. This publication builds upon presentations made and discussions held during the break‐out session ‘Advancing risk assessment science – Human health’ at EFSA's third Scientific Conference ‘Science, Food and Society’ (Parma, Italy, 18–21 September 2018). |
format | Online Article Text |
id | pubmed-7015480 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-70154802020-07-02 Advancing human health risk assessment Lanzoni, Anna Castoldi, Anna F Kass, George EN Terron, Andrea De Seze, Guilhem Bal‐Price, Anna Bois, Frédéric Y Delclos, K Barry Doerge, Daniel R Fritsche, Ellen Halldorsson, Thorhallur Kolossa‐Gehring, Marike Hougaard Bennekou, Susanne Koning, Frits Lampen, Alfonso Leist, Marcel Mantus, Ellen Rousselle, Christophe Siegrist, Michael Steinberg, Pablo Tritscher, Angelika Van de Water, Bob Vineis, Paolo Walker, Nigel Wallace, Heather Whelan, Maurice Younes, Maged EFSA J Advancing Risk Assessment Science The current/traditional human health risk assessment paradigm is challenged by recent scientific and technical advances, and ethical demands. The current approach is considered too resource intensive, is not always reliable, can raise issues of reproducibility, is mostly animal based and does not necessarily provide an understanding of the underlying mechanisms of toxicity. From an ethical and scientific viewpoint, a paradigm shift is required to deliver testing strategies that enable reliable, animal‐free hazard and risk assessments, which are based on a mechanistic understanding of chemical toxicity and make use of exposure science and epidemiological data. This shift will require a new philosophy, new data, multidisciplinary expertise and more flexible regulations. Re‐engineering of available data is also deemed necessary as data should be accessible, readable, interpretable and usable. Dedicated training to build the capacity in terms of expertise is necessary, together with practical resources allocated to education. The dialogue between risk assessors, risk managers, academia and stakeholders should be promoted further to understand scientific and societal needs. Genuine interest in taking risk assessment forward should drive the change and should be supported by flexible funding. This publication builds upon presentations made and discussions held during the break‐out session ‘Advancing risk assessment science – Human health’ at EFSA's third Scientific Conference ‘Science, Food and Society’ (Parma, Italy, 18–21 September 2018). John Wiley and Sons Inc. 2019-07-08 /pmc/articles/PMC7015480/ /pubmed/32626449 http://dx.doi.org/10.2903/j.efsa.2019.e170712 Text en © 2019 European Food Safety Authority. EFSA Journal published by John Wiley and Sons Ltd on behalf of European Food Safety Authority. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited and no modifications or adaptations are made. |
spellingShingle | Advancing Risk Assessment Science Lanzoni, Anna Castoldi, Anna F Kass, George EN Terron, Andrea De Seze, Guilhem Bal‐Price, Anna Bois, Frédéric Y Delclos, K Barry Doerge, Daniel R Fritsche, Ellen Halldorsson, Thorhallur Kolossa‐Gehring, Marike Hougaard Bennekou, Susanne Koning, Frits Lampen, Alfonso Leist, Marcel Mantus, Ellen Rousselle, Christophe Siegrist, Michael Steinberg, Pablo Tritscher, Angelika Van de Water, Bob Vineis, Paolo Walker, Nigel Wallace, Heather Whelan, Maurice Younes, Maged Advancing human health risk assessment |
title | Advancing human health risk assessment |
title_full | Advancing human health risk assessment |
title_fullStr | Advancing human health risk assessment |
title_full_unstemmed | Advancing human health risk assessment |
title_short | Advancing human health risk assessment |
title_sort | advancing human health risk assessment |
topic | Advancing Risk Assessment Science |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7015480/ https://www.ncbi.nlm.nih.gov/pubmed/32626449 http://dx.doi.org/10.2903/j.efsa.2019.e170712 |
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