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Comparison of severity index and plasma paraquat concentration for predicting survival after paraquat poisoning: A meta-analysis

BACKGROUND: Severity index and plasma paraquat (PQ) concentration can predict the prognosis of patients with PQ poisoning. However, the better parameter is yet to be systematically investigated and determined. Thus, we conduct this systematic review and meta-analysis to investigate the prognostic va...

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Autores principales: Cao, Zong Xun, Zhao, Yong, Gao, Jie, Feng, Shun Yi, Wu, Cheng Pu, Zhai, Yan Zhao, Zhang, Meng, Nie, Shen, Li, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7015625/
https://www.ncbi.nlm.nih.gov/pubmed/32028427
http://dx.doi.org/10.1097/MD.0000000000019063
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author Cao, Zong Xun
Zhao, Yong
Gao, Jie
Feng, Shun Yi
Wu, Cheng Pu
Zhai, Yan Zhao
Zhang, Meng
Nie, Shen
Li, Yong
author_facet Cao, Zong Xun
Zhao, Yong
Gao, Jie
Feng, Shun Yi
Wu, Cheng Pu
Zhai, Yan Zhao
Zhang, Meng
Nie, Shen
Li, Yong
author_sort Cao, Zong Xun
collection PubMed
description BACKGROUND: Severity index and plasma paraquat (PQ) concentration can predict the prognosis of patients with PQ poisoning. However, the better parameter is yet to be systematically investigated and determined. Thus, we conduct this systematic review and meta-analysis to investigate the prognostic value of severity index and plasma PQ concentration in patients with PQ poisoning. METHODS: We searched PubMed, Embase, Web of Science, ScienceDirect, and Cochrane Library to identify all relevant papers that were published up to March 2019. All diagnostic studies that compared severity index and plasma PQ concentration to predict mortality in patients with PQ poisoning were enrolled in this meta-analysis. Odds ratios (ORs) with 95% confidence intervals (CIs) for individual trials were pooled using a random-effect model. We also aggregated heterogeneity testing, sensitivity analysis, and publication bias analysis. RESULTS: Ultimately, seven studies involving 821 patients were included. The pooled OR with a 95% CI of severity index was 24.12 (95% CI: 9.34–62.34, P < .001), with an area under the curve of 0.88 (95% CI: 0.85–0.90), sensitivity of 0.84 (95% CI: 0.74–0.91), and specificity of 0.81 (95% CI: 0.75–0.87). Meanwhile, the pooled OR with 95% CI of plasma PQ concentration was 34.39 (95% CI: 14.69–80.56, P < .001), with an area under the curve of 0.94 (95% CI: 0.91–0.96), sensitivity of 0.86 (95% CI: 0.75–0.93), and specificity of 0.89 (95% CI: 0.76–0.95). Sensitivity analysis demonstrated the stability of the results of our meta-analysis. No significant publication bias was observed in this meta-analysis. CONCLUSION: : Overall, this study indicated that severity index and plasma PQ concentration have relatively high-prognostic value in patients with PQ poisoning, and that the sensitivity and specificity of plasma PQ concentration are superior to those of severity index.
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spelling pubmed-70156252020-02-26 Comparison of severity index and plasma paraquat concentration for predicting survival after paraquat poisoning: A meta-analysis Cao, Zong Xun Zhao, Yong Gao, Jie Feng, Shun Yi Wu, Cheng Pu Zhai, Yan Zhao Zhang, Meng Nie, Shen Li, Yong Medicine (Baltimore) 3900 BACKGROUND: Severity index and plasma paraquat (PQ) concentration can predict the prognosis of patients with PQ poisoning. However, the better parameter is yet to be systematically investigated and determined. Thus, we conduct this systematic review and meta-analysis to investigate the prognostic value of severity index and plasma PQ concentration in patients with PQ poisoning. METHODS: We searched PubMed, Embase, Web of Science, ScienceDirect, and Cochrane Library to identify all relevant papers that were published up to March 2019. All diagnostic studies that compared severity index and plasma PQ concentration to predict mortality in patients with PQ poisoning were enrolled in this meta-analysis. Odds ratios (ORs) with 95% confidence intervals (CIs) for individual trials were pooled using a random-effect model. We also aggregated heterogeneity testing, sensitivity analysis, and publication bias analysis. RESULTS: Ultimately, seven studies involving 821 patients were included. The pooled OR with a 95% CI of severity index was 24.12 (95% CI: 9.34–62.34, P < .001), with an area under the curve of 0.88 (95% CI: 0.85–0.90), sensitivity of 0.84 (95% CI: 0.74–0.91), and specificity of 0.81 (95% CI: 0.75–0.87). Meanwhile, the pooled OR with 95% CI of plasma PQ concentration was 34.39 (95% CI: 14.69–80.56, P < .001), with an area under the curve of 0.94 (95% CI: 0.91–0.96), sensitivity of 0.86 (95% CI: 0.75–0.93), and specificity of 0.89 (95% CI: 0.76–0.95). Sensitivity analysis demonstrated the stability of the results of our meta-analysis. No significant publication bias was observed in this meta-analysis. CONCLUSION: : Overall, this study indicated that severity index and plasma PQ concentration have relatively high-prognostic value in patients with PQ poisoning, and that the sensitivity and specificity of plasma PQ concentration are superior to those of severity index. Wolters Kluwer Health 2020-02-07 /pmc/articles/PMC7015625/ /pubmed/32028427 http://dx.doi.org/10.1097/MD.0000000000019063 Text en Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0
spellingShingle 3900
Cao, Zong Xun
Zhao, Yong
Gao, Jie
Feng, Shun Yi
Wu, Cheng Pu
Zhai, Yan Zhao
Zhang, Meng
Nie, Shen
Li, Yong
Comparison of severity index and plasma paraquat concentration for predicting survival after paraquat poisoning: A meta-analysis
title Comparison of severity index and plasma paraquat concentration for predicting survival after paraquat poisoning: A meta-analysis
title_full Comparison of severity index and plasma paraquat concentration for predicting survival after paraquat poisoning: A meta-analysis
title_fullStr Comparison of severity index and plasma paraquat concentration for predicting survival after paraquat poisoning: A meta-analysis
title_full_unstemmed Comparison of severity index and plasma paraquat concentration for predicting survival after paraquat poisoning: A meta-analysis
title_short Comparison of severity index and plasma paraquat concentration for predicting survival after paraquat poisoning: A meta-analysis
title_sort comparison of severity index and plasma paraquat concentration for predicting survival after paraquat poisoning: a meta-analysis
topic 3900
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7015625/
https://www.ncbi.nlm.nih.gov/pubmed/32028427
http://dx.doi.org/10.1097/MD.0000000000019063
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