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Purinergic signaling in cochlear supporting cells reduces hair cell excitability by increasing the extracellular space

Neurons in developing sensory pathways exhibit spontaneous bursts of electrical activity that are critical for survival, maturation and circuit refinement. In the auditory system, intrinsically generated activity arises within the cochlea, but the molecular mechanisms that initiate this activity rem...

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Detalles Bibliográficos
Autores principales: Babola, Travis A, Kersbergen, Calvin J, Wang, Han Chin, Bergles, Dwight E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7015667/
https://www.ncbi.nlm.nih.gov/pubmed/31913121
http://dx.doi.org/10.7554/eLife.52160