The kinesin-5 tail domain directly modulates the mechanochemical cycle of the motor domain for anti-parallel microtubule sliding

Kinesin-5 motors organize mitotic spindles by sliding apart microtubules. They are homotetramers with dimeric motor and tail domains at both ends of a bipolar minifilament. Here, we describe a regulatory mechanism involving direct binding between tail and motor domains and its fundamental role in mi...

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Detalles Bibliográficos
Autores principales: Bodrug, Tatyana, Wilson-Kubalek, Elizabeth M, Nithianantham, Stanley, Thompson, Alex F, Alfieri, April, Gaska, Ignas, Major, Jennifer, Debs, Garrett, Inagaki, Sayaka, Gutierrez, Pedro, Gheber, Larisa, McKenney, Richard J, Sindelar, Charles Vaughn, Milligan, Ronald, Stumpff, Jason, Rosenfeld, Steven S, Forth, Scott T, Al-Bassam, Jawdat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7015671/
https://www.ncbi.nlm.nih.gov/pubmed/31958056
http://dx.doi.org/10.7554/eLife.51131

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7015671/
https://www.ncbi.nlm.nih.gov/pubmed/31958056
http://dx.doi.org/10.7554/eLife.51131

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