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Marked structural rearrangement of mannose 6-phosphate/IGF2 receptor at different pH environments

Many cell surface receptors internalize their ligands and deliver them to endosomes, where the acidic pH causes the ligand to dissociate. The liberated receptor returns to the cell surface in a process called receptor cycling. The structural basis for pH-dependent ligand dissociation is not well und...

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Detalles Bibliográficos
Autores principales:	Wang, Rong, Qi, Xiaofeng, Schmiege, Philip, Coutavas, Elias, Li, Xiaochun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2020
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7015683/ https://www.ncbi.nlm.nih.gov/pubmed/32095534 http://dx.doi.org/10.1126/sciadv.aaz1466

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