Pervasive head-to-tail insertions of DNA templates mask desired CRISPR-Cas9–mediated genome editing events

CRISPR-Cas9–mediated homology-directed DNA repair is the method of choice for precise gene editing in a wide range of model organisms, including mouse and human. Broad use by the biomedical community refined the method, making it more efficient and sequence specific. Nevertheless, the rapidly evolvi...

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Detalles Bibliográficos
Autores principales: Skryabin, Boris V., Kummerfeld, Delf-Magnus, Gubar, Leonid, Seeger, Birte, Kaiser, Helena, Stegemann, Anja, Roth, Johannes, Meuth, Sven G., Pavenstädt, Hermann, Sherwood, Joanna, Pap, Thomas, Wedlich-Söldner, Roland, Sunderkötter, Cord, Schwartz, Yuri B., Brosius, Juergen, Rozhdestvensky, Timofey S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7015686/
https://www.ncbi.nlm.nih.gov/pubmed/32095517
http://dx.doi.org/10.1126/sciadv.aax2941

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