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Aceclofenac fast dispersible tablet formulations: Effect of different concentration levels of Avicel PH102 on the compactional, mechanical and drug release characteristics

The objective of this study was based on the formulation development of fast dispersible Aceclofenac tablets (100 mg) and to evaluate the influence of pharmaceutical mixtures of directly compressible Avicel PH102 with Mannitol and Ac-di-sol on the compressional, mechanical characteristics and drug r...

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Autores principales: Yasmin, Riffat, Shoaib, Muhammad Harris, Ahmed, Farrukh Rafiq, Qazi, Faaiza, Ali, Huma, Zafar, Farya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7015698/
https://www.ncbi.nlm.nih.gov/pubmed/32050259
http://dx.doi.org/10.1371/journal.pone.0223201
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author Yasmin, Riffat
Shoaib, Muhammad Harris
Ahmed, Farrukh Rafiq
Qazi, Faaiza
Ali, Huma
Zafar, Farya
author_facet Yasmin, Riffat
Shoaib, Muhammad Harris
Ahmed, Farrukh Rafiq
Qazi, Faaiza
Ali, Huma
Zafar, Farya
author_sort Yasmin, Riffat
collection PubMed
description The objective of this study was based on the formulation development of fast dispersible Aceclofenac tablets (100 mg) and to evaluate the influence of pharmaceutical mixtures of directly compressible Avicel PH102 with Mannitol and Ac-di-sol on the compressional, mechanical characteristics and drug release properties. Fast dispersible Aceclofenac formulations were developed by central composite design (CCD). Among them the best possible formulation was selected on the basis of micromeritic properties, appropriate tablet weight and disintegration time for further study. Tablets were directly compressed using manual hydraulic press with a compressional force ranging from 7.2 to 77.2 MN/m(2). Pre and post compression studies were performed and the compressed formulations (FA-FF) were assessed for different quality tests. The Heckel and Kawakita equations were applied for determination of compressional behavior of formulations. The quality attributes suggested that formulation (FB) containing avicel PH 102 (20%), mannitol (25%) and ac-di-sol (3%) as best optimized formulation showing better mechanical strength i.e. hardness 35.40 ± 6.93N, tensile strength 0.963 MN/m(2), and friability 0.68%. Furthermore, compressional analysis of FB showed lowest P(Y) value 59.520 MN/m(2) and P(k) value 1.040 MN/m(2) indicating plasticity of the material. Formulation FB disintegrated rapidly within 21 seconds and released 99.92% drug after 45 min in phosphate buffer pH 6.8. Results of drug release kinetics showed that all formulations followed Weibull and First-order models in three different dissolution media. Avicel PH102 based formulation mixture exhibit excellent compactional strength with rapid disintegration and quick drug release.
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spelling pubmed-70156982020-02-26 Aceclofenac fast dispersible tablet formulations: Effect of different concentration levels of Avicel PH102 on the compactional, mechanical and drug release characteristics Yasmin, Riffat Shoaib, Muhammad Harris Ahmed, Farrukh Rafiq Qazi, Faaiza Ali, Huma Zafar, Farya PLoS One Research Article The objective of this study was based on the formulation development of fast dispersible Aceclofenac tablets (100 mg) and to evaluate the influence of pharmaceutical mixtures of directly compressible Avicel PH102 with Mannitol and Ac-di-sol on the compressional, mechanical characteristics and drug release properties. Fast dispersible Aceclofenac formulations were developed by central composite design (CCD). Among them the best possible formulation was selected on the basis of micromeritic properties, appropriate tablet weight and disintegration time for further study. Tablets were directly compressed using manual hydraulic press with a compressional force ranging from 7.2 to 77.2 MN/m(2). Pre and post compression studies were performed and the compressed formulations (FA-FF) were assessed for different quality tests. The Heckel and Kawakita equations were applied for determination of compressional behavior of formulations. The quality attributes suggested that formulation (FB) containing avicel PH 102 (20%), mannitol (25%) and ac-di-sol (3%) as best optimized formulation showing better mechanical strength i.e. hardness 35.40 ± 6.93N, tensile strength 0.963 MN/m(2), and friability 0.68%. Furthermore, compressional analysis of FB showed lowest P(Y) value 59.520 MN/m(2) and P(k) value 1.040 MN/m(2) indicating plasticity of the material. Formulation FB disintegrated rapidly within 21 seconds and released 99.92% drug after 45 min in phosphate buffer pH 6.8. Results of drug release kinetics showed that all formulations followed Weibull and First-order models in three different dissolution media. Avicel PH102 based formulation mixture exhibit excellent compactional strength with rapid disintegration and quick drug release. Public Library of Science 2020-02-12 /pmc/articles/PMC7015698/ /pubmed/32050259 http://dx.doi.org/10.1371/journal.pone.0223201 Text en © 2020 Yasmin et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Yasmin, Riffat
Shoaib, Muhammad Harris
Ahmed, Farrukh Rafiq
Qazi, Faaiza
Ali, Huma
Zafar, Farya
Aceclofenac fast dispersible tablet formulations: Effect of different concentration levels of Avicel PH102 on the compactional, mechanical and drug release characteristics
title Aceclofenac fast dispersible tablet formulations: Effect of different concentration levels of Avicel PH102 on the compactional, mechanical and drug release characteristics
title_full Aceclofenac fast dispersible tablet formulations: Effect of different concentration levels of Avicel PH102 on the compactional, mechanical and drug release characteristics
title_fullStr Aceclofenac fast dispersible tablet formulations: Effect of different concentration levels of Avicel PH102 on the compactional, mechanical and drug release characteristics
title_full_unstemmed Aceclofenac fast dispersible tablet formulations: Effect of different concentration levels of Avicel PH102 on the compactional, mechanical and drug release characteristics
title_short Aceclofenac fast dispersible tablet formulations: Effect of different concentration levels of Avicel PH102 on the compactional, mechanical and drug release characteristics
title_sort aceclofenac fast dispersible tablet formulations: effect of different concentration levels of avicel ph102 on the compactional, mechanical and drug release characteristics
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7015698/
https://www.ncbi.nlm.nih.gov/pubmed/32050259
http://dx.doi.org/10.1371/journal.pone.0223201
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