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Blocking the autocrine regulatory loop of Gankyrin/STAT3/CCL24/CCR3 impairs the progression and pazopanib resistance of clear cell renal cell carcinoma

The poor prognosis of clear-cell renal cell carcinoma (ccRCC) patients is due to progression and targeted drug resistance, but the underlying molecular mechanisms need further elucidation. This study examined the biological function and related mechanisms of gankyrin in ccRCC based on the results of...

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Detalles Bibliográficos
Autores principales: Wang, Chao, Wang, Yuning, Hong, Tianyu, Cheng, Bing, Gan, Sishun, Chen, Linbao, Zhang, Jing, Zuo, Li, Li, Jian, Cui, Xingang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7015941/
https://www.ncbi.nlm.nih.gov/pubmed/32051393
http://dx.doi.org/10.1038/s41419-020-2306-6