Cargando…
Collecting data through high throughput in vitro early toxicity and off-target liability assays to rapidly identify limitations of novel thyromimetics
In order to rapidly identify the phenotypic profile and possible off-target liability effects of novel synthesized thyromimetics for selection of lead compounds for further optimization studies, we performed in vitro screening on a new small library of synthetic thyromimetics. A comprehensive panel...
Autores principales: | Runfola, Massimiliano, Sestito, Simona, Gul, Sheraz, Chiellini, Grazia, Rapposelli, Simona |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7015999/ https://www.ncbi.nlm.nih.gov/pubmed/32071982 http://dx.doi.org/10.1016/j.dib.2020.105206 |
Ejemplares similares
-
Diphenyl-Methane Based Thyromimetic Inhibitors for Transthyretin Amyloidosis
por: Kim, Bokyung, et al.
Publicado: (2021) -
New Multitarget Approaches in the War Against Glioblastoma: A Mini-Perspective
por: Sestito, Simona, et al.
Publicado: (2018) -
Selective Thyroid Hormone Receptor-Beta (TRβ) Agonists: New Perspectives for the Treatment of Metabolic and Neurodegenerative Disorders
por: Saponaro, Federica, et al.
Publicado: (2020) -
SUN-717 SG-2 a Novel Multi-Target Directed Ligand (MTDL) for the Treatment of Neurodegenerative Diseases (NDDS)
por: Sestito, Simona, et al.
Publicado: (2020) -
Beyond Antioxidant Effects: Nature-Based Templates Unveil New Strategies for Neurodegenerative Diseases
por: Bacci, Andrea, et al.
Publicado: (2021)