Cargando…

Dysregulated metabolic pathways in age-related macular degeneration

Age-related macular degeneration is a major cause of vision impairment in the Western world among people of 55 years and older. Recently we have shown that autophagy is dysfunctional in the retinal pigment epithelium (RPE) of the AMD donor eyes (AMD RPE). We also showed increased reactive oxygen (RO...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Meng, Jiang, Nisi, Chu, Yi, Postnikova, Olga, Varghese, Rency, Horvath, Anelia, Cheema, Amrita K., Golestaneh, Nady
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016007/ https://www.ncbi.nlm.nih.gov/pubmed/32051464 http://dx.doi.org/10.1038/s41598-020-59244-4

Ejemplares similares

Dysfunctional autophagy in RPE, a contributing factor in age-related macular degeneration
por: Golestaneh, Nady, et al.
Publicado: (2017)

Pgc-1α repression and high-fat diet induce age-related macular degeneration-like phenotypes in mice
por: Zhang, Meng, et al.
Publicado: (2018)

Repressed SIRT1/PGC-1α pathway and mitochondrial disintegration in iPSC-derived RPE disease model of age-related macular degeneration
por: Golestaneh, Nady, et al.
Publicado: (2016)

Stem cells: a new paradigm for disease modeling and developing therapies for age-related macular degeneration
por: Melville, Heather, et al.
Publicado: (2013)

Stable Intronic Sequences and Exon Skipping Events in the Human RPE65 Gene: Analysis of Expression in Retinal Pigment Epithelium Cells and Cell Culture Models
por: Postnikova, Olga, et al.
Publicado: (2019)

Age-Related Macular Degeneration: A Disease of Systemic or Local Complement Dysregulation?
por: Warwick, Alasdair, et al.
Publicado: (2014)

Dysregulation of Resolvin E1 Metabolism and Signaling in a Light-Damage Model of Age-Related Macular Degeneration
por: Tisi, Annamaria, et al.
Publicado: (2023)

The Role of Dysregulated miRNAs in the Pathogenesis, Diagnosis and Treatment of Age-Related Macular Degeneration
por: Urbańska, Karolina, et al.
Publicado: (2022)

The Anti-Aging Hormone Klotho Promotes Retinal Pigment Epithelium Cell Viability and Metabolism by Activating the AMPK/PGC-1α Pathway
por: Zhou, Shuyan, et al.
Publicado: (2023)

Using a spike-in experiment to evaluate analysis of LC-MS data
por: Tuli, Leepika, et al.
Publicado: (2012)

Role of IL-4 in bone marrow driven dysregulated angiogenesis and age-related macular degeneration
por: Baba, Takashi, et al.
Publicado: (2020)

Autophagy and heterophagy dysregulation leads to retinal pigment epithelium dysfunction and development of age-related macular degeneration
por: Kaarniranta, Kai, et al.
Publicado: (2013)

Diagnostic Markers and Molecular Dysregulation Mechanisms in the Retinal Pigmented Epithelium and Retina of Age-Related Macular Degeneration
por: Li, Yao, et al.
Publicado: (2022)

Age-related macular degeneration.
por: McConnell, V., et al.
Publicado: (2005)

Age-related macular degeneration
por: Querques, Giuseppe, et al.
Publicado: (2011)

Age-related macular degeneration
por: Mathenge, Wanjiku
Publicado: (2014)

Complement activation, lipid metabolism, and mitochondrial injury: Converging pathways in age-related macular degeneration
por: Tan, Li Xuan, et al.
Publicado: (2020)

Transcriptome of rhesus macaque (Macaca mulatta) exposed to total-body irradiation
por: Li, Yaoxiang, et al.
Publicado: (2021)

Dysregulated Tear Film Proteins in Macular Edema Due to the Neovascular Age-Related Macular Degeneration Are Involved in the Regulation of Protein Clearance, Inflammation, and Neovascularization
por: Winiarczyk, Mateusz, et al.
Publicado: (2021)

Cathepsin B pH-Dependent Activity Is Involved in Lysosomal Dysregulation in Atrophic Age-Related Macular Degeneration
por: Voisin, Audrey, et al.
Publicado: (2019)

Is Retinal Metabolic Dysfunction at the Center of the Pathogenesis of Age-related Macular Degeneration?
por: Léveillard, Thierry, et al.
Publicado: (2019)

Age-related macular degeneration and the aging eye
por: Ehrlich, Rita, et al.
Publicado: (2008)

Age-Related Macular Degeneration and the Aging Brain
por: Whitson, Heather, et al.
Publicado: (2021)

Identification of Key Genes and Pathways Associated with Age-Related Macular Degeneration
por: Zhang, Junyu, et al.
Publicado: (2020)

Age‐related macular degeneration and myeloproliferative neoplasms – A common pathway
por: Liisborg, Charlotte
Publicado: (2022)

Pharmacogenetics and Age-Related Macular Degeneration
por: Schwartz, Stephen G., et al.
Publicado: (2011)

Prevention of age-related macular degeneration
por: Wong, Ian Yat Hin, et al.
Publicado: (2010)

Angiogenin in age-related macular degeneration
por: Skeie, Jessica M., et al.
Publicado: (2011)

Pharmacotherapy for Age-Related Macular Degeneration
por: Ahmadieh, Hamid
Publicado: (2008)

Metabolomics and Age-Related Macular Degeneration
por: Brown, Connor N., et al.
Publicado: (2018)

Nanotechnology for Age-Related Macular Degeneration
por: Yang, Bo, et al.
Publicado: (2021)

Neuroprotection for Age-Related Macular Degeneration
por: Lin, Jonathan B., et al.
Publicado: (2022)

Age-Related Macular or Retinal Degeneration?
por: Gałuszka, Michalina, et al.
Publicado: (2023)

LAMELLAR MACULAR HOLES IN THE PRESENCE OF AGE-RELATED MACULAR DEGENERATION
por: Francone, Anibal, et al.
Publicado: (2020)

Complete Transcriptome Profiling of Normal and Age-Related Macular Degeneration Eye Tissues Reveals Dysregulation of Anti-Sense Transcription
por: Kim, Eun Ji, et al.
Publicado: (2018)

Corrigendum to “Cathepsin B pH-Dependent Activity Is Involved in Lysosomal Dysregulation in Atrophic Age-Related Macular Degeneration”
por: Voisin, Audrey, et al.
Publicado: (2020)

DICER1 in the Pathogenesis of Age-related Macular Degeneration (AMD) - Alu RNA Accumulation versus miRNA Dysregulation
por: Kaarniranta, Kai, et al.
Publicado: (2020)

The Plasma NAD(+) Metabolome Is Dysregulated in “Normal” Aging
por: Clement, James, et al.
Publicado: (2019)

Human pharyngeal microbiota in age-related macular degeneration
por: Ho, Eliza Xin Pei, et al.
Publicado: (2018)

Macular and Plasma Xanthophylls Are Higher in Age-related Macular Degeneration than in Normal Aging: Alabama Study on Early Age-related Macular Degeneration 2 Baseline
por: McGwin, Gerald, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_io2hs4gs1fibq2ljrmm7pr0lkd