PDL1 blockage increases fetal resorption and Tfr cells but does not affect Tfh/Tfr ratio and B-cell maturation during allogeneic pregnancy

A successful pregnancy requires sophisticated regulation of uterine microenvironment to guarantee the existence of semi-allogeneic conceptus without immune rejection. T follicular regulatory (Tfr) cells exert a suppressive effect on Tfh-cell expansion, B-cell response, and antibody production. Altho...

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Detalles Bibliográficos
Autores principales: Zeng, Weihong, Qin, Shi, Wang, Renjie, Zhang, Yuchen, Ma, Xiaoling, Tian, Fuju, Liu, Xiao-Rui, Qin, Xiaoli, Liao, Shujie, Sun, Liqun, Lin, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016117/
https://www.ncbi.nlm.nih.gov/pubmed/32051396
http://dx.doi.org/10.1038/s41419-020-2313-7

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