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Quercetin liposomes ameliorate streptozotocin-induced diabetic nephropathy in diabetic rats
The effects of quercetin liposomes (Q-PEGL) on streptozotocin (STZ)-induced diabetic nephropathy (DN) was investigated in rats. Male Sprague Dawley rats were used to establish a STZ induced DN model. DN rats randomly received one of the following treatments for 8 weeks: blank treatment (DN), free qu...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016118/ https://www.ncbi.nlm.nih.gov/pubmed/32051470 http://dx.doi.org/10.1038/s41598-020-59411-7 |
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author | Tang, Lixia Li, Ke Zhang, Yan Li, Huifang Li, Ankang Xu, Yuancheng Wei, Bing |
author_facet | Tang, Lixia Li, Ke Zhang, Yan Li, Huifang Li, Ankang Xu, Yuancheng Wei, Bing |
author_sort | Tang, Lixia |
collection | PubMed |
description | The effects of quercetin liposomes (Q-PEGL) on streptozotocin (STZ)-induced diabetic nephropathy (DN) was investigated in rats. Male Sprague Dawley rats were used to establish a STZ induced DN model. DN rats randomly received one of the following treatments for 8 weeks: blank treatment (DN), free quercetin (Que), pegylated liposomes (PEGL) and pegylated quercetin liposomes (Q-PEGL). A group of healthy rats served as the normal control. The fasting blood glucose (FBG), body weights (BWs), renal hypertrophy index (rHI), serum and urine biochemistry, renal histopathology, oxidative stress and immunohistochemical measurements of AGEs were analyzed to compare the effect of different treatments. Que and Q-PEGL significantly improved DN biochemistry and pathological changes, although the treated rats still had some symptoms of DN. The therapeutic effect of Q-PEGL surpassed that of Que. Pegylated quercetin liposomes allow maintaining higher quercetin concentrations in plasma than non-encapsulated quercetin. In conclusion the use of quercetin liposomes allows to reduce disease symptoms in a rat model of DN. |
format | Online Article Text |
id | pubmed-7016118 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-70161182020-02-21 Quercetin liposomes ameliorate streptozotocin-induced diabetic nephropathy in diabetic rats Tang, Lixia Li, Ke Zhang, Yan Li, Huifang Li, Ankang Xu, Yuancheng Wei, Bing Sci Rep Article The effects of quercetin liposomes (Q-PEGL) on streptozotocin (STZ)-induced diabetic nephropathy (DN) was investigated in rats. Male Sprague Dawley rats were used to establish a STZ induced DN model. DN rats randomly received one of the following treatments for 8 weeks: blank treatment (DN), free quercetin (Que), pegylated liposomes (PEGL) and pegylated quercetin liposomes (Q-PEGL). A group of healthy rats served as the normal control. The fasting blood glucose (FBG), body weights (BWs), renal hypertrophy index (rHI), serum and urine biochemistry, renal histopathology, oxidative stress and immunohistochemical measurements of AGEs were analyzed to compare the effect of different treatments. Que and Q-PEGL significantly improved DN biochemistry and pathological changes, although the treated rats still had some symptoms of DN. The therapeutic effect of Q-PEGL surpassed that of Que. Pegylated quercetin liposomes allow maintaining higher quercetin concentrations in plasma than non-encapsulated quercetin. In conclusion the use of quercetin liposomes allows to reduce disease symptoms in a rat model of DN. Nature Publishing Group UK 2020-02-12 /pmc/articles/PMC7016118/ /pubmed/32051470 http://dx.doi.org/10.1038/s41598-020-59411-7 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Tang, Lixia Li, Ke Zhang, Yan Li, Huifang Li, Ankang Xu, Yuancheng Wei, Bing Quercetin liposomes ameliorate streptozotocin-induced diabetic nephropathy in diabetic rats |
title | Quercetin liposomes ameliorate streptozotocin-induced diabetic nephropathy in diabetic rats |
title_full | Quercetin liposomes ameliorate streptozotocin-induced diabetic nephropathy in diabetic rats |
title_fullStr | Quercetin liposomes ameliorate streptozotocin-induced diabetic nephropathy in diabetic rats |
title_full_unstemmed | Quercetin liposomes ameliorate streptozotocin-induced diabetic nephropathy in diabetic rats |
title_short | Quercetin liposomes ameliorate streptozotocin-induced diabetic nephropathy in diabetic rats |
title_sort | quercetin liposomes ameliorate streptozotocin-induced diabetic nephropathy in diabetic rats |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016118/ https://www.ncbi.nlm.nih.gov/pubmed/32051470 http://dx.doi.org/10.1038/s41598-020-59411-7 |
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