Improving the positional adaptability: structure-based design of biphenyl-substituted diaryltriazines as novel non-nucleoside HIV-1 reverse transcriptase inhibitors

In order to improve the positional adaptability of our previously reported naphthyl diaryltriazines (NP-DATAs), synthesis of a series of novel biphenyl-substituted diaryltriazines (BP-DATAs) with a flexible side chain attached at the C-6 position is presented. These compounds exhibited excellent pot...

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Detalles Bibliográficos
Autores principales: Jin, Kaijun, Liu, Minjie, Zhuang, Chunlin, De Clercq, Erik, Pannecouque, Christophe, Meng, Ge, Chen, Fener
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016291/
https://www.ncbi.nlm.nih.gov/pubmed/32082978
http://dx.doi.org/10.1016/j.apsb.2019.09.007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016291/
https://www.ncbi.nlm.nih.gov/pubmed/32082978
http://dx.doi.org/10.1016/j.apsb.2019.09.007

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