Cargando…

Mangiferin Alleviates Renal Interstitial Fibrosis in Streptozotocin-Induced Diabetic Mice through Regulating the PTEN/PI3K/Akt Signaling Pathway

Renal interstitial fibrosis is considered to be the typical manifestation of diabetic nephropathy (DN). Mangiferin has shown positive effect on the prevention or treatment of diabetes and its complications. The aim of this study was to explore the inhibitive effect and mechanism of mangiferin on ren...

Descripción completa

Detalles Bibliográficos
Autores principales:	Song, Yanyan, Liu, Wei, Tang, Ke, Zang, Junting, Li, Dong, Gao, Hang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016412/ https://www.ncbi.nlm.nih.gov/pubmed/32076626 http://dx.doi.org/10.1155/2020/9481720

Ejemplares similares

Knockdown of miR-214 Alleviates Renal Interstitial Fibrosis by Targeting the Regulation of the PTEN/PI3K/AKT Signalling Pathway
por: Hou, DongHua, et al.
Publicado: (2022)

Research Progress of PI3K/PTEN/AKT Signaling Pathway Associated with Renal Cell Carcinoma
por: Fang, Yakun, et al.
Publicado: (2022)

Mangiferin attenuates oxidative stress induced renal cell damage through activation of PI3K induced Akt and Nrf-2 mediated signaling pathways
por: Saha, Sukanya, et al.
Publicado: (2016)

Ruxolitinib Alleviates Renal Interstitial Fibrosis in UUO Mice
por: Bai, Yu, et al.
Publicado: (2020)

Inhibition of miR‐188‐5p alleviates hepatic fibrosis by significantly reducing the activation and proliferation of HSCs through PTEN/PI3K/AKT pathway
por: Riaz, Farooq, et al.
Publicado: (2021)

Quercetin alleviates chronic renal failure by targeting the PI3k/Akt pathway
por: Tu, Haitao, et al.
Publicado: (2021)

Retracted: Research Progress of PI3K/PTEN/AKT Signaling Pathway Associated with Renal Cell Carcinoma
por: Markers, Disease
Publicado: (2023)

The PTEN/PI3K/AKT Pathway in vivo, Cancer Mouse Models
por: Carnero, Amancio, et al.
Publicado: (2014)

Dysregulation of PI3K/Akt/PTEN Pathway in Canine Mammary Tumor
por: Kim, Soo-Hyeon, et al.
Publicado: (2021)

Mangiferin inhibits cell migration and angiogenesis via PI3K/AKT/mTOR signaling in high glucose- and hypoxia-induced RRCECs
por: Shi, Jia, et al.
Publicado: (2021)

PTEN regulation of the proliferation and differentiation of auditory progenitors through the PTEN/PI3K/Akt-signaling pathway in mice
por: Sun, Chen, et al.
Publicado: (2014)

PI3K/AKT/PTEN Signaling as a Molecular Target in Leukemia Angiogenesis
por: Okumura, Naoko, et al.
Publicado: (2012)

Roles of PI3K/AKT/PTEN Pathway as a Target for Pharmaceutical Therapy
por: Matsuda, Satoru, et al.
Publicado: (2013)

PI3K/AKT activation induces PTEN ubiquitination and destabilization accelerating tumourigenesis
por: Lee, Min-Sik, et al.
Publicado: (2015)

miR-21 antagonist alleviates colitis and angiogenesis via the PTEN/PI3K/AKT pathway in colitis mice induced by TNBS
por: Xie, Xiaoran, et al.
Publicado: (2022)

[Retracted] SIRT1 promotes tumorigenesis of hepatocellular carcinoma through PI3K/PTEN/AKT signaling
por: Wang, Hanning, et al.
Publicado: (2023)

Protective Nature of Mangiferin on Oxidative Stress and Antioxidant Status in Tissues of Streptozotocin-Induced Diabetic Rats
por: Sellamuthu, Periyar Selvam, et al.
Publicado: (2013)

Metformin alleviates the calcification of aortic valve interstitial cells through activating the PI3K/AKT pathway in an AMPK dependent way
por: En, Qiao, et al.
Publicado: (2021)

Triptolide Restores Autophagy to Alleviate Diabetic Renal Fibrosis through the miR-141-3p/PTEN/Akt/mTOR Pathway
por: Li, Xiao-yu, et al.
Publicado: (2017)

Dapagliflozin can alleviate renal fibrosis in rats with streptozotocin‑induced type 2 diabetes mellitus
por: Xue, Song, et al.
Publicado: (2023)

Tetrandrine inhibits proliferation of colon cancer cells by BMP9/ PTEN/ PI3K/AKT signaling
por: Zhou, Ya, et al.
Publicado: (2019)

SALL4 suppresses PTEN expression to promote glioma cell proliferation via PI3K/AKT signaling pathway
por: Liu, Chuanjin, et al.
Publicado: (2017)

miRNA-186 Improves Sepsis Induced Renal Injury Via PTEN/PI3K/AKT/P53 Pathway
por: Li, Min, et al.
Publicado: (2020)

Rhein alleviates renal interstitial fibrosis by inhibiting tubular cell apoptosis in rats
por: Chen, Yakun, et al.
Publicado: (2019)

Mangiferin relieves CCl4-induced liver fibrosis in mice
por: Zhang, Lijun, et al.
Publicado: (2023)

IFN-τ mediated miR-26a targeting PTEN to activate PI3K/AKT signalling to alleviate the inflammatory damage of bEECs
por: Liu, Junfeng, et al.
Publicado: (2022)

The PTEN–PI3K Axis in Cancer
por: Papa, Antonella, et al.
Publicado: (2019)

Roles for PI3K/AKT/PTEN Pathway in Cell Signaling of Nonalcoholic Fatty Liver Disease
por: Matsuda, Satoru, et al.
Publicado: (2013)

Implications of PI3K/AKT/PTEN Signaling on Superoxide Dismutases Expression and in the Pathogenesis of Alzheimer’s Disease
por: Matsuda, Satoru, et al.
Publicado: (2018)

Physiological levels of the PTEN-PI3K-AKT axis activity are required for maintenance of Burkitt lymphoma
por: Gehringer, Franziska, et al.
Publicado: (2019)

Author Correction: PI3K/AKT activation induces PTEN ubiquitination and destabilization accelerating tumourigenesis
por: Lee, Min-Sik, et al.
Publicado: (2020)

YB-1 Oncoprotein Controls PI3K/Akt Pathway by Reducing Pten Protein Level
por: Delicato, Antonella, et al.
Publicado: (2021)

The PI3K/AKT Pathway and PTEN Gene Are Involved in “Tree-Top Disease” of Lymantria dispar
por: Li, Fengjiao, et al.
Publicado: (2022)

lncNALT knockdown ameliorates hypertensive retinopathy via PTEN/PI3K/AKT pathway
por: Kang, Haijun, et al.
Publicado: (2023)

Chinese herbal decoction astragalus and angelica exerts its therapeutic effect on renal interstitial fibrosis through the inhibition of MAPK, PI3K-Akt and TNF signaling pathways
por: Yuan, Hao, et al.
Publicado: (2020)

miR-29c Inhibits Renal Interstitial Fibrotic Proliferative Properties through PI3K-AKT Pathway
por: Feng, Weifeng, et al.
Publicado: (2022)

Baicalin alleviates bleomycin-induced pulmonary fibrosis and fibroblast proliferation in rats via the PI3K/AKT signaling pathway
por: Zhao, Hong, et al.
Publicado: (2020)

Inhibition of Disruptor of Telomeric Silencing 1-Like Alleviated Renal Ischemia and Reperfusion Injury-Induced Fibrosis by Blocking PI3K/AKT-Mediated Oxidative Stress
por: Yang, Chuan, et al.
Publicado: (2019)

Mangiferin Alleviates Postpartum Depression–Like Behaviors by Inhibiting MAPK Signaling in Microglia
por: Yan, Meichen, et al.
Publicado: (2022)

Mangiferin Potentiates Neuroprotection by Isoflurane in Neonatal Hypoxic Brain Injury by Reducing Oxidative Stress and Activation of Phosphatidylinositol-3-Kinase/Akt/Mammalian Target of Rapamycin (PI3K/Akt/mTOR) Signaling
por: Xi, Jia-shui, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_8pm4ks752j64j2k1tdndbgnb2f