Cargando…

Discovery of sulfone-resistant dihydropteroate synthase (DHPS) as a target enzyme for kaempferol, a natural flavanoid

Kaempferol is a ubiquitous flavonoid, found in various plants having a wide range of known pharmacological activities, including antioxidant, antiinflammatory, anticancer, antiallergic, antidiabetic, neuroprotective, cardioprotective and antimicrobial activities. Nonetheless various evidence suggest...

Descripción completa

Detalles Bibliográficos
Autores principales:	Potshangbam, Angamba Meetei, Rathore, Ravindranath Singh, Nongdam, Potshangbam
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016458/ https://www.ncbi.nlm.nih.gov/pubmed/32083215 http://dx.doi.org/10.1016/j.heliyon.2020.e03378

Ejemplares similares

NeMedPlant: a database of therapeutic applications and chemical constituents of medicinal plants from north-east region of India
por: Meetei, Potshangbam Angamba, et al.
Publicado: (2012)

In silico screening for identification of novel β-1,3-glucan synthase inhibitors using pharmacophore and 3D-QSAR methodologies
por: Meetei, Potshangbam Angamba, et al.
Publicado: (2016)

Evaluation of genetic relationship between 15 bamboo species of North-East India based on ISSR marker analysis
por: Amom, Thoungamba, et al.
Publicado: (2018)

Update on Dihydropteroate Synthase (DHPS) Mutations in Pneumocystis jirovecii
por: de la Horra, Carmen, et al.
Publicado: (2021)

Hyperoxidation of Peroxiredoxin 6 Induces Alteration from Dimeric to Oligomeric State
por: Shahnaj, Sharifun, et al.
Publicado: (2019)

Genetic Variability of Plasmodium malariae dihydropteroate synthase (dhps) in Four Asian Countries
por: Tanomsing, Naowarat, et al.
Publicado: (2014)

OrFin: A web tool for detection of putative orthologs
por: Midha, Mohit, et al.
Publicado: (2012)

Establishment of an Efficient In Vitro Regeneration Protocol for Rapid and Mass Propagation of Dendrobium chrysotoxum Lindl. Using Seed Culture
por: Nongdam, Potshangbam, et al.
Publicado: (2014)

Limited Polymorphism in the Dihydrofolate Reductase (dhfr) and dihydropteroate synthase genes (dhps) of Plasmodium knowlesi isolate from Thailand
por: Sangsri, Raweewan, et al.
Publicado: (2023)

Genetic Diversity of Dihydropteroate synthetase Gene (dhps) of Plasmodium vivax in Hormozgan Province, Iran
por: MAGHSOODLOORAD, Somayeh, et al.
Publicado: (2016)

Low Prevalence of Pneumocystis pneumonia (PCP) but High Prevalence of Pneumocystis dihydropteroate synthase (dhps) Gene Mutations in HIV-Infected Persons in Uganda
por: Taylor, Steve M., et al.
Publicado: (2012)

ISSR Marker Based Population Genetic Study of Melocanna baccifera (Roxb.) Kurz: A Commercially Important Bamboo of Manipur, North-East India
por: Nilkanta, Heikrujam, et al.
Publicado: (2017)

Declining trend of Plasmodium falciparum dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) mutant alleles after the withdrawal of Sulfadoxine-Pyrimethamine in North Western Ethiopia
por: Tessema, Sofonias K., et al.
Publicado: (2015)

Genetic mutations in Plasmodium falciparum and Plasmodium vivax dihydrofolate reductase (DHFR) and dihydropteroate synthase (DHPS) in Vanuatu and Solomon Islands prior to the introduction of artemisinin combination therapy
por: Gresty, Karryn J, et al.
Publicado: (2014)

Reactive oxygen species scavenging mechanisms associated with polyethylene glycol mediated osmotic stress tolerance in Chinese potato
por: Sahoo, Manas Ranjan, et al.
Publicado: (2020)

Sub-microscopic Plasmodium falciparum parasitaemia, dihydropteroate synthase (dhps) resistance mutations to sulfadoxine–pyrimethamine, transmission intensity and risk of malaria infection in pregnancy in Mount Cameroon Region
por: Mbacham, Harry F., et al.
Publicado: (2023)

Anti-folate drug resistance in Africa: meta-analysis of reported dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) mutant genotype frequencies in African Plasmodium falciparum parasite populations
por: Sridaran, Sankar, et al.
Publicado: (2010)

Low prevalence of dihydro folate reductase (dhfr) and dihydropteroate synthase (dhps) quadruple and quintuple mutant alleles associated with SP resistance in Plasmodium vivax isolates of West Bengal, India
por: Das, Sabyasachi, et al.
Publicado: (2016)

Bioactive flavanoids from Glycosmis arborea
por: Khan, Mohammad Faheem, et al.
Publicado: (2013)

Crystal structures of Burkholderia cenocepacia dihydropteroate synthase in the apo-form and complexed with the product 7,8-dihydropteroate
por: Morgan, Rachel E, et al.
Publicado: (2011)

Dihydropteroate Synthase Gene Mutations in Pneumocystis and Sulfa Resistance
por: Huang, Laurence, et al.
Publicado: (2004)

Identification and Characterization of an Allosteric Inhibitory Site on Dihydropteroate Synthase
por: Hammoudeh, Dalia I., et al.
Publicado: (2014)

The effects of flavanoid on the treatment of hepatopulmonary syndrome
por: Atalay, Talha, et al.
Publicado: (2013)

Sulfa Use, Dihydropteroate Synthase Mutations, and Pneumocystis jirovecii Pneumonia
por: Stein, Cheryl R., et al.
Publicado: (2004)

Sulfa Resistance and Dihydropteroate Synthase Mutants in Recurrent Pneumocystis carinii Pneumonia
por: Nahimana, Aimable, et al.
Publicado: (2003)

Crystal Structure of the 6-Hydroxymethyl-7,8-Dihydropterin Pyrophosphokinase•Dihydropteroate Synthase Bifunctional Enzyme from Francisella tularensis
por: Pemble, Charles W., et al.
Publicado: (2010)

Anticancer Applications and Pharmacological Properties of Piperidine and Piperine: A Comprehensive Review on Molecular Mechanisms and Therapeutic Perspectives
por: Mitra, Sicon, et al.
Publicado: (2022)

Overview of the Biological Activity of Anthraquinons and Flavanoids of the Plant Rumex Species
por: Berillo, Dmitriy, et al.
Publicado: (2022)

Pneumocystis jiroveci Dihydropteroate Synthase Genotypes in Immunocompetent Infants and Immunosuppressed Adults, Amiens, France
por: Totet, Anne, et al.
Publicado: (2004)

Orchid Micropropagation Using Conventional Semi-Solid and Temporary Immersion Systems: A Review
por: Nongdam, Potshangbam, et al.
Publicado: (2023)

Polymorphism in drug resistance genes dihydrofolate reductase and dihydropteroate synthase in Plasmodium falciparum in some states of India
por: Sharma, Divya, et al.
Publicado: (2015)

Antiviral actions of flavanoid-derived compounds on dengue virus type-2
por: Muhamad, Mudiana, et al.
Publicado: (2010)

Surveillance of Dihydropteroate Synthase Genes in Stenotrophomonas maltophilia by LAMP: Implications for Infection Control and Initial Therapy
por: Zhao, Jin, et al.
Publicado: (2016)

The Structural and Functional Basis for Recurring Sulfa Drug Resistance Mutations in Staphylococcus aureus Dihydropteroate Synthase
por: Griffith, Elizabeth C., et al.
Publicado: (2018)

Low prevalence of highly sulfadoxine‐resistant dihydropteroate synthase alleles in Plasmodium falciparum isolates in Benin
por: Svigel, Samaly Souza, et al.
Publicado: (2021)

In vitro Antibacterial Activity and Resistance Prevention of Antimicrobial Combinations for Dihydropteroate Synthase-Carrying Stenotrophomonas maltophilia
por: Zhao, Jin, et al.
Publicado: (2022)

Sulphonamide resistant commensal Neisseria with alterations in the dihydropteroate synthase can be isolated from carriers not exposed to sulphonamides
por: Qvarnström, Yvonne, et al.
Publicado: (2002)

Mutational analysis of Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase genes in the interior division of Sabah, Malaysia
por: Lau, Tiek Ying, et al.
Publicado: (2013)

Genetic Polymorphisms in Plasmodium vivax Dihydrofolate Reductase and Dihydropteroate Synthase in Isolates from the Philippines, Bangladesh, and Nepal
por: Thongdee, Pimwan, et al.
Publicado: (2015)

A new Mycobacterium leprae dihydropteroate synthase variant (V39I) from Papua, Indonesia
por: Maladan, Yustinus, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_6d5m9313nf9e702ta3tci8a3cm