CD14 and ALPK1 Affect Expression of Tight Junction Components and Proinflammatory Mediators upon Bacterial Stimulation in a Colonic 3D Organoid Model

Cd14 and Alpk1 both encode pathogen recognition receptors and are known candidate genes for affecting severity in inflammatory bowel diseases. CD14 acts as a coreceptor for bacterial lipopolysaccharide (LPS), while ALPK1 senses ADP-D-glycero-beta-D-manno-heptose, a metabolic intermediate of LPS bios...

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Detalles Bibliográficos
Autores principales: Brooks, Pascal, zur Bruegge, Talke, Boyle, Erin C., Kalies, Stefan, Villarreal, Santiago Nahuel, Liese, Andrea, Bleich, André, Buettner, Manuela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016478/
https://www.ncbi.nlm.nih.gov/pubmed/32076438
http://dx.doi.org/10.1155/2020/4069354

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