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Effects of unilateral cortical resection of the visual cortex on bilateral human white matter

Children with unilateral resections of ventral occipito-temporal cortex (VOTC) typically do not evince visual perceptual impairments, even when relatively large swathes of VOTC are resected. In search of possible explanations for this behavioral competence, we evaluated white matter microstructure a...

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Autores principales: Maallo, Anne Margarette S., Freud, Erez, Liu, Tina Tong, Patterson, Christina, Behrmann, Marlene
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016507/
https://www.ncbi.nlm.nih.gov/pubmed/31712165
http://dx.doi.org/10.1016/j.neuroimage.2019.116345
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author Maallo, Anne Margarette S.
Freud, Erez
Liu, Tina Tong
Patterson, Christina
Behrmann, Marlene
author_facet Maallo, Anne Margarette S.
Freud, Erez
Liu, Tina Tong
Patterson, Christina
Behrmann, Marlene
author_sort Maallo, Anne Margarette S.
collection PubMed
description Children with unilateral resections of ventral occipito-temporal cortex (VOTC) typically do not evince visual perceptual impairments, even when relatively large swathes of VOTC are resected. In search of possible explanations for this behavioral competence, we evaluated white matter microstructure and connectivity in eight pediatric epilepsy patients following unilateral cortical resection and 15 age-matched controls. To uncover both local and broader resection-induced effects, we analyzed tractography data using two complementary approaches. First, the microstructural properties were measured in the inferior longitudinal and the inferior fronto-occipital fasciculi, the major VOTC association tracts. Group differences were only evident in the ipsilesional, and not in the contralesional, hemisphere, and single-subject analyses revealed that these differences were limited to the site of the resection. Second, graph theory was used to characterize the connectivity of the contralesional occipito-temporal regions. There were no changes to the network properties in patients with left VOTC resections nor in patients with resections outside the VOTC, but altered network efficiency was observed in two cases with right VOTC resections. These results suggest that, in many, although perhaps not all, cases of unilateral VOTC resections in childhood, the white matter profile in the preserved contralesional hemisphere along with residual neural activity might be sufficient for normal visual perception.
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spelling pubmed-70165072020-02-15 Effects of unilateral cortical resection of the visual cortex on bilateral human white matter Maallo, Anne Margarette S. Freud, Erez Liu, Tina Tong Patterson, Christina Behrmann, Marlene Neuroimage Article Children with unilateral resections of ventral occipito-temporal cortex (VOTC) typically do not evince visual perceptual impairments, even when relatively large swathes of VOTC are resected. In search of possible explanations for this behavioral competence, we evaluated white matter microstructure and connectivity in eight pediatric epilepsy patients following unilateral cortical resection and 15 age-matched controls. To uncover both local and broader resection-induced effects, we analyzed tractography data using two complementary approaches. First, the microstructural properties were measured in the inferior longitudinal and the inferior fronto-occipital fasciculi, the major VOTC association tracts. Group differences were only evident in the ipsilesional, and not in the contralesional, hemisphere, and single-subject analyses revealed that these differences were limited to the site of the resection. Second, graph theory was used to characterize the connectivity of the contralesional occipito-temporal regions. There were no changes to the network properties in patients with left VOTC resections nor in patients with resections outside the VOTC, but altered network efficiency was observed in two cases with right VOTC resections. These results suggest that, in many, although perhaps not all, cases of unilateral VOTC resections in childhood, the white matter profile in the preserved contralesional hemisphere along with residual neural activity might be sufficient for normal visual perception. 2019-11-09 2020-02-15 /pmc/articles/PMC7016507/ /pubmed/31712165 http://dx.doi.org/10.1016/j.neuroimage.2019.116345 Text en This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Maallo, Anne Margarette S.
Freud, Erez
Liu, Tina Tong
Patterson, Christina
Behrmann, Marlene
Effects of unilateral cortical resection of the visual cortex on bilateral human white matter
title Effects of unilateral cortical resection of the visual cortex on bilateral human white matter
title_full Effects of unilateral cortical resection of the visual cortex on bilateral human white matter
title_fullStr Effects of unilateral cortical resection of the visual cortex on bilateral human white matter
title_full_unstemmed Effects of unilateral cortical resection of the visual cortex on bilateral human white matter
title_short Effects of unilateral cortical resection of the visual cortex on bilateral human white matter
title_sort effects of unilateral cortical resection of the visual cortex on bilateral human white matter
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016507/
https://www.ncbi.nlm.nih.gov/pubmed/31712165
http://dx.doi.org/10.1016/j.neuroimage.2019.116345
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