Cargando…
On ATG4B as Drug Target for Treatment of Solid Tumours—The Knowns and the Unknowns
Autophagy is an evolutionary conserved stress survival pathway that has been shown to play an important role in the initiation, progression, and metastasis of multiple cancers; however, little progress has been made to date in translation of basic research to clinical application. This is partially...
Autores principales: | Agrotis, Alexander, Ketteler, Robin |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016753/ https://www.ncbi.nlm.nih.gov/pubmed/31878323 http://dx.doi.org/10.3390/cells9010053 |
Ejemplares similares
-
Redundancy of human ATG4 protease isoforms in autophagy and LC3/GABARAP processing revealed in cells
por: Agrotis, Alexander, et al.
Publicado: (2019) -
A reversible phospho-switch mediated by ULK1 regulates the activity of autophagy protease ATG4B
por: Pengo, N., et al.
Publicado: (2017) -
Human ATG4 autophagy proteases counteract attachment of ubiquitin-like LC3/GABARAP proteins to other cellular proteins
por: Agrotis, Alexander, et al.
Publicado: (2019) -
Identification of Kinases and Phosphatases That Regulate ATG4B Activity by siRNA and Small Molecule Screening in Cells
por: Pengo, Niccolo, et al.
Publicado: (2018) -
A new age in functional genomics using CRISPR/Cas9 in arrayed library screening
por: Agrotis, Alexander, et al.
Publicado: (2015)