Oxidative DNA Damage Modulates DNA Methylation Pattern in Human Breast Cancer 1 (BRCA1) Gene via the Crosstalk between DNA Polymerase β and a de novo DNA Methyltransferase

DNA damage and base excision repair (BER) are actively involved in the modulation of DNA methylation and demethylation. However, the underlying molecular mechanisms remain unclear. In this study, we seek to understand the mechanisms by exploring the effects of oxidative DNA damage on the DNA methyla...

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Detalles Bibliográficos
Autores principales: Jiang, Zhongliang, Lai, Yanhao, Beaver, Jill M., Tsegay, Pawlos S., Zhao, Ming-Lang, Horton, Julie K., Zamora, Marco, Rein, Hayley L., Miralles, Frank, Shaver, Mohammad, Hutcheson, Joshua D., Agoulnik, Irina, Wilson, Samuel H., Liu, Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016758/
https://www.ncbi.nlm.nih.gov/pubmed/31963223
http://dx.doi.org/10.3390/cells9010225

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