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Signaling Network of Forkhead Family of Transcription Factors (FOXO) in Dietary Restriction
Dietary restriction (DR), which is defined as a reduction of particular or total nutrient intake without causing malnutrition, has been proved to be a robust way to extend both lifespan and health-span in various species from yeast to mammal. However, the molecular mechanisms by which DR confers ben...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016766/ https://www.ncbi.nlm.nih.gov/pubmed/31906091 http://dx.doi.org/10.3390/cells9010100 |
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author | Jiang, Yizhou Yan, Fengxia Feng, Zhongping Lazarovici, Philip Zheng, Wenhua |
author_facet | Jiang, Yizhou Yan, Fengxia Feng, Zhongping Lazarovici, Philip Zheng, Wenhua |
author_sort | Jiang, Yizhou |
collection | PubMed |
description | Dietary restriction (DR), which is defined as a reduction of particular or total nutrient intake without causing malnutrition, has been proved to be a robust way to extend both lifespan and health-span in various species from yeast to mammal. However, the molecular mechanisms by which DR confers benefits on longevity were not yet fully elucidated. The forkhead box O transcription factors (FOXOs), identified as downstream regulators of the insulin/IGF-1 signaling pathway, control the expression of many genes regulating crucial biological processes such as metabolic homeostasis, redox balance, stress response and cell viability and proliferation. The activity of FOXOs is also mediated by AMP-activated protein kinase (AMPK), sirtuins and the mammalian target of rapamycin (mTOR). Therefore, the FOXO-related pathways form a complex network critical for coordinating a response to environmental fluctuations in order to maintain cellular homeostasis and to support physiological aging. In this review, we will focus on the role of FOXOs in different DR interventions. As different DR regimens or calorie (energy) restriction mimetics (CRMs) can elicit both distinct and overlapped DR-related signaling pathways, the benefits of DR may be maximized by combining diverse forms of interventions. In addition, a better understanding of the precise role of FOXOs in different mechanistic aspects of DR response would provide clear cellular and molecular insights on DR-induced increase of lifespan and health-span. |
format | Online Article Text |
id | pubmed-7016766 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-70167662020-02-28 Signaling Network of Forkhead Family of Transcription Factors (FOXO) in Dietary Restriction Jiang, Yizhou Yan, Fengxia Feng, Zhongping Lazarovici, Philip Zheng, Wenhua Cells Review Dietary restriction (DR), which is defined as a reduction of particular or total nutrient intake without causing malnutrition, has been proved to be a robust way to extend both lifespan and health-span in various species from yeast to mammal. However, the molecular mechanisms by which DR confers benefits on longevity were not yet fully elucidated. The forkhead box O transcription factors (FOXOs), identified as downstream regulators of the insulin/IGF-1 signaling pathway, control the expression of many genes regulating crucial biological processes such as metabolic homeostasis, redox balance, stress response and cell viability and proliferation. The activity of FOXOs is also mediated by AMP-activated protein kinase (AMPK), sirtuins and the mammalian target of rapamycin (mTOR). Therefore, the FOXO-related pathways form a complex network critical for coordinating a response to environmental fluctuations in order to maintain cellular homeostasis and to support physiological aging. In this review, we will focus on the role of FOXOs in different DR interventions. As different DR regimens or calorie (energy) restriction mimetics (CRMs) can elicit both distinct and overlapped DR-related signaling pathways, the benefits of DR may be maximized by combining diverse forms of interventions. In addition, a better understanding of the precise role of FOXOs in different mechanistic aspects of DR response would provide clear cellular and molecular insights on DR-induced increase of lifespan and health-span. MDPI 2019-12-31 /pmc/articles/PMC7016766/ /pubmed/31906091 http://dx.doi.org/10.3390/cells9010100 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Jiang, Yizhou Yan, Fengxia Feng, Zhongping Lazarovici, Philip Zheng, Wenhua Signaling Network of Forkhead Family of Transcription Factors (FOXO) in Dietary Restriction |
title | Signaling Network of Forkhead Family of Transcription Factors (FOXO) in Dietary Restriction |
title_full | Signaling Network of Forkhead Family of Transcription Factors (FOXO) in Dietary Restriction |
title_fullStr | Signaling Network of Forkhead Family of Transcription Factors (FOXO) in Dietary Restriction |
title_full_unstemmed | Signaling Network of Forkhead Family of Transcription Factors (FOXO) in Dietary Restriction |
title_short | Signaling Network of Forkhead Family of Transcription Factors (FOXO) in Dietary Restriction |
title_sort | signaling network of forkhead family of transcription factors (foxo) in dietary restriction |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016766/ https://www.ncbi.nlm.nih.gov/pubmed/31906091 http://dx.doi.org/10.3390/cells9010100 |
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