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Schizosaccharomyces pombe Assays to Study Mitotic Recombination Outcomes

The fission yeast—Schizosaccharomyces pombe—has emerged as a powerful tractable system for studying DNA damage repair. Over the last few decades, several powerful in vivo genetic assays have been developed to study outcomes of mitotic recombination, the major repair mechanism of DNA double strand br...

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Detalles Bibliográficos
Autores principales: Hylton, Hannah M., Lucas, Bailey E., Petreaca, Ruben C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016768/
https://www.ncbi.nlm.nih.gov/pubmed/31936815
http://dx.doi.org/10.3390/genes11010079
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author Hylton, Hannah M.
Lucas, Bailey E.
Petreaca, Ruben C.
author_facet Hylton, Hannah M.
Lucas, Bailey E.
Petreaca, Ruben C.
author_sort Hylton, Hannah M.
collection PubMed
description The fission yeast—Schizosaccharomyces pombe—has emerged as a powerful tractable system for studying DNA damage repair. Over the last few decades, several powerful in vivo genetic assays have been developed to study outcomes of mitotic recombination, the major repair mechanism of DNA double strand breaks and stalled or collapsed DNA replication forks. These assays have significantly increased our understanding of the molecular mechanisms underlying the DNA damage response pathways. Here, we review the assays that have been developed in fission yeast to study mitotic recombination.
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spelling pubmed-70167682020-02-28 Schizosaccharomyces pombe Assays to Study Mitotic Recombination Outcomes Hylton, Hannah M. Lucas, Bailey E. Petreaca, Ruben C. Genes (Basel) Review The fission yeast—Schizosaccharomyces pombe—has emerged as a powerful tractable system for studying DNA damage repair. Over the last few decades, several powerful in vivo genetic assays have been developed to study outcomes of mitotic recombination, the major repair mechanism of DNA double strand breaks and stalled or collapsed DNA replication forks. These assays have significantly increased our understanding of the molecular mechanisms underlying the DNA damage response pathways. Here, we review the assays that have been developed in fission yeast to study mitotic recombination. MDPI 2020-01-10 /pmc/articles/PMC7016768/ /pubmed/31936815 http://dx.doi.org/10.3390/genes11010079 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Hylton, Hannah M.
Lucas, Bailey E.
Petreaca, Ruben C.
Schizosaccharomyces pombe Assays to Study Mitotic Recombination Outcomes
title Schizosaccharomyces pombe Assays to Study Mitotic Recombination Outcomes
title_full Schizosaccharomyces pombe Assays to Study Mitotic Recombination Outcomes
title_fullStr Schizosaccharomyces pombe Assays to Study Mitotic Recombination Outcomes
title_full_unstemmed Schizosaccharomyces pombe Assays to Study Mitotic Recombination Outcomes
title_short Schizosaccharomyces pombe Assays to Study Mitotic Recombination Outcomes
title_sort schizosaccharomyces pombe assays to study mitotic recombination outcomes
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016768/
https://www.ncbi.nlm.nih.gov/pubmed/31936815
http://dx.doi.org/10.3390/genes11010079
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