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Lentiform Nucleus Hyperechogenicity in Parkinsonian Syndromes: A Systematic Review and Meta-Analysis with Consideration of Molecular Pathology

The hyperechogenicity of the substania nigra (SN) has been established as a valid finding in patients with Parkinson’s disease (PD), probably caused by an increased tissue iron concentration in the SN. The application of transcranial sonography (TCS) has been investigated for further echogenic basal...

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Autores principales: Richter, Daniel, Katsanos, Aristeidis H., Schroeder, Christoph, Tsivgoulis, Georgios, Paraskevas, George P., Müller, Thomas, Alexandrov, Andrei V., Gold, Ralf, Tönges, Lars, Krogias, Christos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016776/
https://www.ncbi.nlm.nih.gov/pubmed/31861253
http://dx.doi.org/10.3390/cells9010002
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author Richter, Daniel
Katsanos, Aristeidis H.
Schroeder, Christoph
Tsivgoulis, Georgios
Paraskevas, George P.
Müller, Thomas
Alexandrov, Andrei V.
Gold, Ralf
Tönges, Lars
Krogias, Christos
author_facet Richter, Daniel
Katsanos, Aristeidis H.
Schroeder, Christoph
Tsivgoulis, Georgios
Paraskevas, George P.
Müller, Thomas
Alexandrov, Andrei V.
Gold, Ralf
Tönges, Lars
Krogias, Christos
author_sort Richter, Daniel
collection PubMed
description The hyperechogenicity of the substania nigra (SN) has been established as a valid finding in patients with Parkinson’s disease (PD), probably caused by an increased tissue iron concentration in the SN. The application of transcranial sonography (TCS) has been investigated for further echogenic basal ganglia alterations in patients with extrapyramidal movement disorders. Compared to PD, a hyperechogenic nucleus lentiformis (LN) has been reported to appear more frequently in atypical parkinsonian syndromes (aPS) such as the parkinsonian phenotype of multiple system atrophy (MSA-P) or the progressive supranuclear palsy (PSP). As the evidence providing study sizes are small, we conduct the first meta-analysis of the prevalence of LN hyperechogenicity in PD and aPS. We search for available studies providing prevalence of LN hyperechogenicity in patients with PD and aPS (MSA-P and PSP) detected by TCS in MEDLINE and SCOPUS databases. We calculate the prevalence rates of LN hyperechogenicity detection in patients with clinical diagnosis of PD vs. aPS under the random-effects model. We include a total of 1330 patients, 1091 PD and 239 aPS (MSA-P and PSP). We find a significantly higher prevalence of LN hyperechogenicity in aPS (76%, 95% CI: 0.62-0.88) compared to PD (16%, 95% CI: 0.10-0.23). After proving a higher prevalence of LN hyperechogenicity in aPS compared to PD, its histopathological cause needs to be investigated. Furthermore, its full diagnostic accuracy and the qualification to serve as a risk factor for MSA-P and PSP should also be questioned in future studies.
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spelling pubmed-70167762020-02-28 Lentiform Nucleus Hyperechogenicity in Parkinsonian Syndromes: A Systematic Review and Meta-Analysis with Consideration of Molecular Pathology Richter, Daniel Katsanos, Aristeidis H. Schroeder, Christoph Tsivgoulis, Georgios Paraskevas, George P. Müller, Thomas Alexandrov, Andrei V. Gold, Ralf Tönges, Lars Krogias, Christos Cells Article The hyperechogenicity of the substania nigra (SN) has been established as a valid finding in patients with Parkinson’s disease (PD), probably caused by an increased tissue iron concentration in the SN. The application of transcranial sonography (TCS) has been investigated for further echogenic basal ganglia alterations in patients with extrapyramidal movement disorders. Compared to PD, a hyperechogenic nucleus lentiformis (LN) has been reported to appear more frequently in atypical parkinsonian syndromes (aPS) such as the parkinsonian phenotype of multiple system atrophy (MSA-P) or the progressive supranuclear palsy (PSP). As the evidence providing study sizes are small, we conduct the first meta-analysis of the prevalence of LN hyperechogenicity in PD and aPS. We search for available studies providing prevalence of LN hyperechogenicity in patients with PD and aPS (MSA-P and PSP) detected by TCS in MEDLINE and SCOPUS databases. We calculate the prevalence rates of LN hyperechogenicity detection in patients with clinical diagnosis of PD vs. aPS under the random-effects model. We include a total of 1330 patients, 1091 PD and 239 aPS (MSA-P and PSP). We find a significantly higher prevalence of LN hyperechogenicity in aPS (76%, 95% CI: 0.62-0.88) compared to PD (16%, 95% CI: 0.10-0.23). After proving a higher prevalence of LN hyperechogenicity in aPS compared to PD, its histopathological cause needs to be investigated. Furthermore, its full diagnostic accuracy and the qualification to serve as a risk factor for MSA-P and PSP should also be questioned in future studies. MDPI 2019-12-18 /pmc/articles/PMC7016776/ /pubmed/31861253 http://dx.doi.org/10.3390/cells9010002 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Richter, Daniel
Katsanos, Aristeidis H.
Schroeder, Christoph
Tsivgoulis, Georgios
Paraskevas, George P.
Müller, Thomas
Alexandrov, Andrei V.
Gold, Ralf
Tönges, Lars
Krogias, Christos
Lentiform Nucleus Hyperechogenicity in Parkinsonian Syndromes: A Systematic Review and Meta-Analysis with Consideration of Molecular Pathology
title Lentiform Nucleus Hyperechogenicity in Parkinsonian Syndromes: A Systematic Review and Meta-Analysis with Consideration of Molecular Pathology
title_full Lentiform Nucleus Hyperechogenicity in Parkinsonian Syndromes: A Systematic Review and Meta-Analysis with Consideration of Molecular Pathology
title_fullStr Lentiform Nucleus Hyperechogenicity in Parkinsonian Syndromes: A Systematic Review and Meta-Analysis with Consideration of Molecular Pathology
title_full_unstemmed Lentiform Nucleus Hyperechogenicity in Parkinsonian Syndromes: A Systematic Review and Meta-Analysis with Consideration of Molecular Pathology
title_short Lentiform Nucleus Hyperechogenicity in Parkinsonian Syndromes: A Systematic Review and Meta-Analysis with Consideration of Molecular Pathology
title_sort lentiform nucleus hyperechogenicity in parkinsonian syndromes: a systematic review and meta-analysis with consideration of molecular pathology
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016776/
https://www.ncbi.nlm.nih.gov/pubmed/31861253
http://dx.doi.org/10.3390/cells9010002
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