A Review of FoxO1-Regulated Metabolic Diseases and Related Drug Discoveries

FoxO1 is a conserved transcription factor involved in energy metabolism. It is tightly regulated by modifications on its mRNA and protein and responds to environmental nutrient signals. FoxO1 controls the transcription of downstream genes mediating metabolic regulation. Dysfunction of FoxO1 pathways...

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Autores principales: Peng, Shiming, Li, Wei, Hou, Nannan, Huang, Niu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016779/
https://www.ncbi.nlm.nih.gov/pubmed/31936903
http://dx.doi.org/10.3390/cells9010184
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author Peng, Shiming
Li, Wei
Hou, Nannan
Huang, Niu
author_facet Peng, Shiming
Li, Wei
Hou, Nannan
Huang, Niu
author_sort Peng, Shiming
collection PubMed
description FoxO1 is a conserved transcription factor involved in energy metabolism. It is tightly regulated by modifications on its mRNA and protein and responds to environmental nutrient signals. FoxO1 controls the transcription of downstream genes mediating metabolic regulation. Dysfunction of FoxO1 pathways results in several metabolic diseases, including diabetes, obesity, non-alcoholic fatty liver disease, and atherosclerosis. Here, we summarize the mechanism of FoxO1 regulation behind these diseases and FoxO1-related drug discoveries.
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spelling pubmed-70167792020-02-28 A Review of FoxO1-Regulated Metabolic Diseases and Related Drug Discoveries Peng, Shiming Li, Wei Hou, Nannan Huang, Niu Cells Review FoxO1 is a conserved transcription factor involved in energy metabolism. It is tightly regulated by modifications on its mRNA and protein and responds to environmental nutrient signals. FoxO1 controls the transcription of downstream genes mediating metabolic regulation. Dysfunction of FoxO1 pathways results in several metabolic diseases, including diabetes, obesity, non-alcoholic fatty liver disease, and atherosclerosis. Here, we summarize the mechanism of FoxO1 regulation behind these diseases and FoxO1-related drug discoveries. MDPI 2020-01-10 /pmc/articles/PMC7016779/ /pubmed/31936903 http://dx.doi.org/10.3390/cells9010184 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Peng, Shiming
Li, Wei
Hou, Nannan
Huang, Niu
A Review of FoxO1-Regulated Metabolic Diseases and Related Drug Discoveries
title A Review of FoxO1-Regulated Metabolic Diseases and Related Drug Discoveries
title_full A Review of FoxO1-Regulated Metabolic Diseases and Related Drug Discoveries
title_fullStr A Review of FoxO1-Regulated Metabolic Diseases and Related Drug Discoveries
title_full_unstemmed A Review of FoxO1-Regulated Metabolic Diseases and Related Drug Discoveries
title_short A Review of FoxO1-Regulated Metabolic Diseases and Related Drug Discoveries
title_sort review of foxo1-regulated metabolic diseases and related drug discoveries
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016779/
https://www.ncbi.nlm.nih.gov/pubmed/31936903
http://dx.doi.org/10.3390/cells9010184
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