Neurofilaments: The C-Reactive Protein of Neurology

Neurofilaments (NFs) are quickly becoming the biomarkers of choice in the field of neurology, suggesting their use as an unspecific screening marker, much like the use of elevated plasma C-reactive protein (CRP) in other fields. With sensitive techniques being readily available, evidence is growing...

Descripción completa

Detalles Bibliográficos
Autores principales: Lambertsen, Kate L., Soares, Catarina B., Gaist, David, Nielsen, Helle H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016784/
https://www.ncbi.nlm.nih.gov/pubmed/31963750
http://dx.doi.org/10.3390/brainsci10010056
_version_ 1783497054901764096
author Lambertsen, Kate L.
Soares, Catarina B.
Gaist, David
Nielsen, Helle H.
author_facet Lambertsen, Kate L.
Soares, Catarina B.
Gaist, David
Nielsen, Helle H.
author_sort Lambertsen, Kate L.
collection PubMed
description Neurofilaments (NFs) are quickly becoming the biomarkers of choice in the field of neurology, suggesting their use as an unspecific screening marker, much like the use of elevated plasma C-reactive protein (CRP) in other fields. With sensitive techniques being readily available, evidence is growing regarding the diagnostic and prognostic value of NFs in many neurological disorders. Here, we review the latest literature on the structure and function of NFs and report the strengths and pitfalls of NFs as markers of neurodegeneration in the context of neurological diseases of the central and peripheral nervous systems.
format Online
Article
Text
id pubmed-7016784
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-70167842020-02-28 Neurofilaments: The C-Reactive Protein of Neurology Lambertsen, Kate L. Soares, Catarina B. Gaist, David Nielsen, Helle H. Brain Sci Review Neurofilaments (NFs) are quickly becoming the biomarkers of choice in the field of neurology, suggesting their use as an unspecific screening marker, much like the use of elevated plasma C-reactive protein (CRP) in other fields. With sensitive techniques being readily available, evidence is growing regarding the diagnostic and prognostic value of NFs in many neurological disorders. Here, we review the latest literature on the structure and function of NFs and report the strengths and pitfalls of NFs as markers of neurodegeneration in the context of neurological diseases of the central and peripheral nervous systems. MDPI 2020-01-18 /pmc/articles/PMC7016784/ /pubmed/31963750 http://dx.doi.org/10.3390/brainsci10010056 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lambertsen, Kate L.
Soares, Catarina B.
Gaist, David
Nielsen, Helle H.
Neurofilaments: The C-Reactive Protein of Neurology
title Neurofilaments: The C-Reactive Protein of Neurology
title_full Neurofilaments: The C-Reactive Protein of Neurology
title_fullStr Neurofilaments: The C-Reactive Protein of Neurology
title_full_unstemmed Neurofilaments: The C-Reactive Protein of Neurology
title_short Neurofilaments: The C-Reactive Protein of Neurology
title_sort neurofilaments: the c-reactive protein of neurology
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016784/
https://www.ncbi.nlm.nih.gov/pubmed/31963750
http://dx.doi.org/10.3390/brainsci10010056
work_keys_str_mv AT lambertsenkatel neurofilamentsthecreactiveproteinofneurology
AT soarescatarinab neurofilamentsthecreactiveproteinofneurology
AT gaistdavid neurofilamentsthecreactiveproteinofneurology
AT nielsenhelleh neurofilamentsthecreactiveproteinofneurology

Ejemplares similares