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Engineered Maturation Approaches of Human Pluripotent Stem Cell-Derived Ventricular Cardiomyocytes

Heart diseases such as myocardial infarction and myocardial ischemia are paroxysmal and fatal in clinical practice. Cardiomyocytes (CMs) differentiated from human pluripotent stem cells provide a promising approach to myocardium regeneration therapy. Identifying the maturity level of human pluripote...

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Detalles Bibliográficos
Autores principales: Ge, Feixiang, Wang, Zetian, Xi, Jianzhong Jeff
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016801/
https://www.ncbi.nlm.nih.gov/pubmed/31861463
http://dx.doi.org/10.3390/cells9010009
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author Ge, Feixiang
Wang, Zetian
Xi, Jianzhong Jeff
author_facet Ge, Feixiang
Wang, Zetian
Xi, Jianzhong Jeff
author_sort Ge, Feixiang
collection PubMed
description Heart diseases such as myocardial infarction and myocardial ischemia are paroxysmal and fatal in clinical practice. Cardiomyocytes (CMs) differentiated from human pluripotent stem cells provide a promising approach to myocardium regeneration therapy. Identifying the maturity level of human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) is currently the main challenge for pathophysiology and therapeutics. In this review, we describe current maturity indicators for cardiac microtissue and microdevice cultivation technologies that accelerate cardiac maturation. It may provide insights into regenerative medicine, drug cardiotoxicity testing, and preclinical safety testing.
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spelling pubmed-70168012020-02-28 Engineered Maturation Approaches of Human Pluripotent Stem Cell-Derived Ventricular Cardiomyocytes Ge, Feixiang Wang, Zetian Xi, Jianzhong Jeff Cells Review Heart diseases such as myocardial infarction and myocardial ischemia are paroxysmal and fatal in clinical practice. Cardiomyocytes (CMs) differentiated from human pluripotent stem cells provide a promising approach to myocardium regeneration therapy. Identifying the maturity level of human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) is currently the main challenge for pathophysiology and therapeutics. In this review, we describe current maturity indicators for cardiac microtissue and microdevice cultivation technologies that accelerate cardiac maturation. It may provide insights into regenerative medicine, drug cardiotoxicity testing, and preclinical safety testing. MDPI 2019-12-18 /pmc/articles/PMC7016801/ /pubmed/31861463 http://dx.doi.org/10.3390/cells9010009 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ge, Feixiang
Wang, Zetian
Xi, Jianzhong Jeff
Engineered Maturation Approaches of Human Pluripotent Stem Cell-Derived Ventricular Cardiomyocytes
title Engineered Maturation Approaches of Human Pluripotent Stem Cell-Derived Ventricular Cardiomyocytes
title_full Engineered Maturation Approaches of Human Pluripotent Stem Cell-Derived Ventricular Cardiomyocytes
title_fullStr Engineered Maturation Approaches of Human Pluripotent Stem Cell-Derived Ventricular Cardiomyocytes
title_full_unstemmed Engineered Maturation Approaches of Human Pluripotent Stem Cell-Derived Ventricular Cardiomyocytes
title_short Engineered Maturation Approaches of Human Pluripotent Stem Cell-Derived Ventricular Cardiomyocytes
title_sort engineered maturation approaches of human pluripotent stem cell-derived ventricular cardiomyocytes
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016801/
https://www.ncbi.nlm.nih.gov/pubmed/31861463
http://dx.doi.org/10.3390/cells9010009
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