Cargando…
Current Therapeutic Strategies for Glioblastoma
Glioblastomas (GB) are grade 4 brain tumors, one of the most aggressive forms of brain cancer found in humans. Although current treatments for GB are largely ineffective, new alternate approaches, beyond standard chemo- or radiation therapies have shown promising results in both pre-clinical and cli...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016852/ https://www.ncbi.nlm.nih.gov/pubmed/31888004 http://dx.doi.org/10.3390/brainsci10010015 |
_version_ | 1783497070894645248 |
---|---|
author | Rossignol, Julien Srinageshwar, Bhairavi Dunbar, Gary L. |
author_facet | Rossignol, Julien Srinageshwar, Bhairavi Dunbar, Gary L. |
author_sort | Rossignol, Julien |
collection | PubMed |
description | Glioblastomas (GB) are grade 4 brain tumors, one of the most aggressive forms of brain cancer found in humans. Although current treatments for GB are largely ineffective, new alternate approaches, beyond standard chemo- or radiation therapies have shown promising results in both pre-clinical and clinical settings. Some of these approaches include stem cell therapy, new pharmaceuticals and nutraceuticals, and the use of tumor specific peptides or GB-targeted antibodies and immune-based therapies. A common limitation in the efficacy of these treatments is the inability of these therapeutic agents to readily cross the blood–brain barrier (BBB) to reach the tumor site. Therefore, many strategies are being developed to achieve targeted delivery of drugs across the BBB so that they can kill the cancer cells, while sparing healthy tissue. One of the most promising new approaches involves the use of nanoparticles that can carry therapeutic drugs and genes across the BBB and home in on the GB tumor site. |
format | Online Article Text |
id | pubmed-7016852 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-70168522020-02-28 Current Therapeutic Strategies for Glioblastoma Rossignol, Julien Srinageshwar, Bhairavi Dunbar, Gary L. Brain Sci Editorial Glioblastomas (GB) are grade 4 brain tumors, one of the most aggressive forms of brain cancer found in humans. Although current treatments for GB are largely ineffective, new alternate approaches, beyond standard chemo- or radiation therapies have shown promising results in both pre-clinical and clinical settings. Some of these approaches include stem cell therapy, new pharmaceuticals and nutraceuticals, and the use of tumor specific peptides or GB-targeted antibodies and immune-based therapies. A common limitation in the efficacy of these treatments is the inability of these therapeutic agents to readily cross the blood–brain barrier (BBB) to reach the tumor site. Therefore, many strategies are being developed to achieve targeted delivery of drugs across the BBB so that they can kill the cancer cells, while sparing healthy tissue. One of the most promising new approaches involves the use of nanoparticles that can carry therapeutic drugs and genes across the BBB and home in on the GB tumor site. MDPI 2019-12-26 /pmc/articles/PMC7016852/ /pubmed/31888004 http://dx.doi.org/10.3390/brainsci10010015 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Editorial Rossignol, Julien Srinageshwar, Bhairavi Dunbar, Gary L. Current Therapeutic Strategies for Glioblastoma |
title | Current Therapeutic Strategies for Glioblastoma |
title_full | Current Therapeutic Strategies for Glioblastoma |
title_fullStr | Current Therapeutic Strategies for Glioblastoma |
title_full_unstemmed | Current Therapeutic Strategies for Glioblastoma |
title_short | Current Therapeutic Strategies for Glioblastoma |
title_sort | current therapeutic strategies for glioblastoma |
topic | Editorial |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016852/ https://www.ncbi.nlm.nih.gov/pubmed/31888004 http://dx.doi.org/10.3390/brainsci10010015 |
work_keys_str_mv | AT rossignoljulien currenttherapeuticstrategiesforglioblastoma AT srinageshwarbhairavi currenttherapeuticstrategiesforglioblastoma AT dunbargaryl currenttherapeuticstrategiesforglioblastoma |