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Current Therapeutic Strategies for Glioblastoma

Glioblastomas (GB) are grade 4 brain tumors, one of the most aggressive forms of brain cancer found in humans. Although current treatments for GB are largely ineffective, new alternate approaches, beyond standard chemo- or radiation therapies have shown promising results in both pre-clinical and cli...

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Autores principales: Rossignol, Julien, Srinageshwar, Bhairavi, Dunbar, Gary L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016852/
https://www.ncbi.nlm.nih.gov/pubmed/31888004
http://dx.doi.org/10.3390/brainsci10010015
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author Rossignol, Julien
Srinageshwar, Bhairavi
Dunbar, Gary L.
author_facet Rossignol, Julien
Srinageshwar, Bhairavi
Dunbar, Gary L.
author_sort Rossignol, Julien
collection PubMed
description Glioblastomas (GB) are grade 4 brain tumors, one of the most aggressive forms of brain cancer found in humans. Although current treatments for GB are largely ineffective, new alternate approaches, beyond standard chemo- or radiation therapies have shown promising results in both pre-clinical and clinical settings. Some of these approaches include stem cell therapy, new pharmaceuticals and nutraceuticals, and the use of tumor specific peptides or GB-targeted antibodies and immune-based therapies. A common limitation in the efficacy of these treatments is the inability of these therapeutic agents to readily cross the blood–brain barrier (BBB) to reach the tumor site. Therefore, many strategies are being developed to achieve targeted delivery of drugs across the BBB so that they can kill the cancer cells, while sparing healthy tissue. One of the most promising new approaches involves the use of nanoparticles that can carry therapeutic drugs and genes across the BBB and home in on the GB tumor site.
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spelling pubmed-70168522020-02-28 Current Therapeutic Strategies for Glioblastoma Rossignol, Julien Srinageshwar, Bhairavi Dunbar, Gary L. Brain Sci Editorial Glioblastomas (GB) are grade 4 brain tumors, one of the most aggressive forms of brain cancer found in humans. Although current treatments for GB are largely ineffective, new alternate approaches, beyond standard chemo- or radiation therapies have shown promising results in both pre-clinical and clinical settings. Some of these approaches include stem cell therapy, new pharmaceuticals and nutraceuticals, and the use of tumor specific peptides or GB-targeted antibodies and immune-based therapies. A common limitation in the efficacy of these treatments is the inability of these therapeutic agents to readily cross the blood–brain barrier (BBB) to reach the tumor site. Therefore, many strategies are being developed to achieve targeted delivery of drugs across the BBB so that they can kill the cancer cells, while sparing healthy tissue. One of the most promising new approaches involves the use of nanoparticles that can carry therapeutic drugs and genes across the BBB and home in on the GB tumor site. MDPI 2019-12-26 /pmc/articles/PMC7016852/ /pubmed/31888004 http://dx.doi.org/10.3390/brainsci10010015 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Editorial
Rossignol, Julien
Srinageshwar, Bhairavi
Dunbar, Gary L.
Current Therapeutic Strategies for Glioblastoma
title Current Therapeutic Strategies for Glioblastoma
title_full Current Therapeutic Strategies for Glioblastoma
title_fullStr Current Therapeutic Strategies for Glioblastoma
title_full_unstemmed Current Therapeutic Strategies for Glioblastoma
title_short Current Therapeutic Strategies for Glioblastoma
title_sort current therapeutic strategies for glioblastoma
topic Editorial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016852/
https://www.ncbi.nlm.nih.gov/pubmed/31888004
http://dx.doi.org/10.3390/brainsci10010015
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