Assessment of Tumor Mutational Burden in Pediatric Tumors by Real-Life Whole-Exome Sequencing and In Silico Simulation of Targeted Gene Panels: How the Choice of Method Could Affect the Clinical Decision?

Background: Tumor mutational burden (TMB) is an emerging genomic biomarker in cancer that has been associated with improved response to immune checkpoint inhibitors (ICIs) in adult cancers. It was described that variability in TMB assessment is introduced by different laboratory techniques and vario...

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Detalles Bibliográficos
Autores principales: Noskova, Hana, Kyr, Michal, Pal, Karol, Merta, Tomas, Mudry, Peter, Polaskova, Kristyna, Ivkovic, Tina Catela, Adamcova, Sona, Hornakova, Tekla, Jezova, Marta, Kren, Leos, Sterba, Jaroslav, Slaby, Ondrej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016876/
https://www.ncbi.nlm.nih.gov/pubmed/31963488
http://dx.doi.org/10.3390/cancers12010230

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