Cargando…
PML/RARa Interferes with NRF2 Transcriptional Activity Increasing the Sensitivity to Ascorbate of Acute Promyelocytic Leukemia Cells
NRF2 (NF-E2 p45-related factor 2) orchestrates cellular adaptive responses to stress. Its quantity and subcellular location is controlled through a complex network and its activity increases during redox perturbation, inflammation, growth factor stimulation, and energy fluxes. Even before all-trans...
Autores principales: | Banella, Cristina, Catalano, Gianfranco, Travaglini, Serena, Divona, Mariadomenica, Masciarelli, Silvia, Guerrera, Gisella, Fazi, Francesco, Lo-Coco, Francesco, Voso, Maria Teresa, Noguera, Nelida Ines |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016898/ https://www.ncbi.nlm.nih.gov/pubmed/31905996 http://dx.doi.org/10.3390/cancers12010095 |
Ejemplares similares
-
Ascorbate Plus Buformin in AML: A Metabolic Targeted Treatment
por: Banella, Cristina, et al.
Publicado: (2022) -
PML/RARa inhibits PTEN expression in hematopoietic cells by competing with PU.1 transcriptional activity
por: Noguera, Nélida Inés, et al.
Publicado: (2016) -
The forkhead box C1 (FOXC1) transcription factor is downregulated in acute promyelocytic leukemia
por: Fabiani, Emiliano, et al.
Publicado: (2017) -
Retinoic acid and arsenic trioxide sensitize acute promyelocytic leukemia cells to ER stress
por: Masciarelli, S, et al.
Publicado: (2018) -
Acute Promyelocytic Leukemia: Update on the Mechanisms of Leukemogenesis, Resistance and on Innovative Treatment Strategies
por: Noguera, N. I., et al.
Publicado: (2019)