Cargando…

LRP1-Mediated AggLDL Endocytosis Promotes Cholesteryl Ester Accumulation and Impairs Insulin Response in HL-1 Cells

The cardiovascular disease (CVD) frequently developed during metabolic syndrome and type-2 diabetes mellitus is associated with increased levels of aggregation-prone small LDL particles. Aggregated LDL (aggLDL) internalization is mediated by low-density lipoprotein receptor-related protein-1 (LRP1)...

Descripción completa

Detalles Bibliográficos
Autores principales:	Actis Dato, Virginia, Benitez-Amaro, Aleyda, de Gonzalo-Calvo, David, Vazquez, Maximiliano, Bonacci, Gustavo, Llorente-Cortés, Vicenta, Chiabrando, Gustavo Alberto
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016900/ https://www.ncbi.nlm.nih.gov/pubmed/31936892 http://dx.doi.org/10.3390/cells9010182

Ejemplares similares

Activated Alpha-2 Macroglobulin Improves Insulin Response via LRP1 in Lipid-Loaded HL-1 Cardiomyocytes
por: Actis Dato, Virginia, et al.
Publicado: (2021)

Inhibitory Effects of LRP1-Based Immunotherapy on Cardiac Extracellular Matrix Biophysical Alterations Induced by Hypercholesterolemia
por: Samouillan, Valerie, et al.
Publicado: (2023)

Peptides against Low Density Lipoprotein (LDL) Aggregation Inhibit Intracellular Cholesteryl Ester Loading and Proliferation of Pancreatic Tumor Cells
por: Benitez-Amaro, Aleyda, et al.
Publicado: (2022)

LRP1 mediates the IGF-1-induced GLUT1 expression on the cell surface and glucose uptake in Müller glial cells
por: Actis Dato, Virginia, et al.
Publicado: (2021)

Nitro-oleic acid, a ligand of CD36, reduces cholesterol accumulation by modulating oxidized-LDL uptake and cholesterol efflux in RAW264.7 macrophages
por: Vazquez, Matias M., et al.
Publicado: (2020)

Apolipoprotein and LRP1-Based Peptides as New Therapeutic Tools in Atherosclerosis
por: Benitez Amaro, Aleyda, et al.
Publicado: (2021)

The Role of Low-Density Lipoprotein Receptor-Related Protein 1 in Lipid Metabolism, Glucose Homeostasis and Inflammation
por: Actis Dato, Virginia, et al.
Publicado: (2018)

Transcriptional analysis reveals that the intracellular lipid accumulation impairs gene expression profiles involved in insulin response-associated cardiac functionality
por: Dato, Virginia Actis, et al.
Publicado: (2023)

Transcriptional analysis reveals that the intracellular lipid accumulation impairs gene expression profiles involved in insulin response-associated cardiac functionality
por: Actis Dato, Virginia, et al.
Publicado: (2023)

Activated α(2)-Macroglobulin Regulates LRP1 Levels at the Plasma Membrane through the Activation of a Rab10-dependent Exocytic Pathway in Retinal Müller Glial Cells
por: Jaldín-Fincati, Javier R., et al.
Publicado: (2019)

Relationship among LRP1 expression, Pyk2 phosphorylation and MMP‐9 activation in left ventricular remodelling after myocardial infarction
por: Revuelta‐López, Elena, et al.
Publicado: (2017)

Prostate cancer cell proliferation is influenced by LDL-cholesterol availability and cholesteryl ester turnover
por: Raftopulos, Nikki L., et al.
Publicado: (2022)

High-capacity selective uptake of cholesteryl ester from native LDL during macrophage foam cell formation
por: Meyer, Jason M., et al.
Publicado: (2012)

Intratumor cholesteryl ester accumulation is associated with human breast cancer proliferation and aggressive potential: a molecular and clinicopathological study
por: de Gonzalo-Calvo, David, et al.
Publicado: (2015)

Low density lipoprotein receptor-related protein 1 expression correlates with cholesteryl ester accumulation in the myocardium of ischemic cardiomyopathy patients
por: Cal, Roi, et al.
Publicado: (2012)

KIF13B enhances the endocytosis of LRP1 by recruiting LRP1 to caveolae
por: Kanai, Yoshimitsu, et al.
Publicado: (2014)

Increased sLRP1 and decreased atrial natriuretic peptide plasma levels in newly diagnosed T2DM patients are normalized after optimization of glycemic control
por: García, Eduardo, et al.
Publicado: (2023)

Cholesterol is Inefficiently Converted to Cholesteryl Esters in the Blood of Cardiovascular Disease Patients
por: Gerl, Mathias J., et al.
Publicado: (2018)

Immunization with the Gly(1127)-Cys(1140) amino acid sequence of the LRP1 receptor reduces atherosclerosis in rabbits. Molecular, immunohistochemical and nuclear imaging studies
por: Bornachea, Olga, et al.
Publicado: (2020)

Approaches to Visualising Endocytosis of LDL-Related Lipoproteins
por: Siddiqui, Halima, et al.
Publicado: (2022)

Cholesteryl ester transfer protein: at the heart of the action of lipid-modulating therapy with statins, fibrates, niacin, and cholesteryl ester transfer protein inhibitors
por: Chapman, M. John, et al.
Publicado: (2010)

Decreased low-density lipoprotein receptor-related protein 1 expression in pro-inflammatory monocytes is associated with subclinical atherosclerosis
por: Albertini, Ricardo A., et al.
Publicado: (2022)

Hemin induces autophagy in a leukemic erythroblast cell line through the LRP1 receptor
por: Grosso, Ruben Adrian, et al.
Publicado: (2019)

Clathrin and LRP-1-Independent Constitutive Endocytosis and Recycling of uPAR
por: Cortese, Katia, et al.
Publicado: (2008)

Assessing the mechanisms of cholesteryl ester transfer protein inhibitors
por: Zhang, Meng, et al.
Publicado: (2017)

Ectodomains of the LDL Receptor-Related Proteins LRP1b and LRP4 Have Anchorage Independent Functions In Vivo
por: Dietrich, Martin F., et al.
Publicado: (2010)

BMP-9 and LDL crosstalk regulates ALK-1 endocytosis and LDL transcytosis in endothelial cells
por: Tao, Bo, et al.
Publicado: (2021)

Reversible accumulation of cholesteryl esters in macrophages incubated with acetylated lipoproteins
Publicado: (1979)

Cholesteryl ester transfer protein inhibitors for dyslipidemia: focus on dalcetrapib
por: Goldberg, Alyse S, et al.
Publicado: (2012)

Cholesteryl Ester Transfer Protein Gene Polymorphisms and Longevity Syndrome
por: Kolovou, Genovefa, et al.
Publicado: (2010)

Cholesteryl Ester Transfer Protein (CETP) Deficiency and CETP Inhibitors
por: Mabuchi, Hiroshi, et al.
Publicado: (2014)

Fluorescent Sterols and Cholesteryl Esters as Probes for Intracellular Cholesterol Transport
por: Solanko, Katarzyna A., et al.
Publicado: (2016)

Structure-based mechanism and inhibition of cholesteryl ester transfer protein
por: Xue, Han, et al.
Publicado: (2023)

LRP4 LDLα repeats of astrocyte enhance dendrite arborization of the neuron
por: Yan, Min, et al.
Publicado: (2020)

Effect of AGG Interruptions on FMR1 Maternal Transmissions
por: Villate, Olatz, et al.
Publicado: (2020)

Mathematical Model for Low Density Lipoprotein (LDL) Endocytosis by Hepatocytes
por: Wattis, J. A. D., et al.
Publicado: (2008)

3D Molecular Imaging of Stratum Corneum by Mass Spectrometry Suggests Distinct Distribution of Cholesteryl Esters Compared to Other Skin Lipids
por: Sjövall, Peter, et al.
Publicado: (2022)

Concentration dependent cholesteryl-ester and wax-ester structural relationships and meibomian gland dysfunction
por: Hetman, Zofia A., et al.
Publicado: (2020)

LDL Receptor-Related Protein-1 (LRP1) Regulates Cholesterol Accumulation in Macrophages
por: Lillis, Anna P., et al.
Publicado: (2015)

Cholesteryl Ester Transfer Protein Gene and Effectiveness of Lipid Lowering of Atorvastatin
por: Kolovou, Genovefa, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_50qnj6gd4lg7c2c3j395d381l3