Glutamine Synthetase 1 Increases Autophagy Lysosomal Degradation of Mutant Huntingtin Aggregates in Neurons, Ameliorating Motility in a Drosophila Model for Huntington’s Disease

Glutamine Synthetase 1 (GS1) is a key enzyme that catalyzes the ATP-dependent synthesis of l-glutamine from l-glutamate and is also member of the Glutamate Glutamine Cycle, a complex physiological process between glia and neurons that controls glutamate homeostasis and is often found compromised in...

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Detalles Bibliográficos
Autores principales: Vernizzi, Luisa, Paiardi, Chiara, Licata, Giusimaria, Vitali, Teresa, Santarelli, Stefania, Raneli, Martino, Manelli, Vera, Rizzetto, Manuela, Gioria, Mariarosa, Pasini, Maria E., Grifoni, Daniela, Vanoni, Maria A., Gellera, Cinzia, Taroni, Franco, Bellosta, Paola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016901/
https://www.ncbi.nlm.nih.gov/pubmed/31941072
http://dx.doi.org/10.3390/cells9010196

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