Characterization of the Menin-MLL Interaction as Therapeutic Cancer Target

Inhibiting the interaction of menin with the histone methyltransferase MLL1 (KMT2A) has recently emerged as a novel therapeutic strategy. Beneficial therapeutic effects have been postulated in leukemia, prostate, breast, liver and in synovial sarcoma models. In those indications, MLL1 recruitment by...

Descripción completa

Detalles Bibliográficos
Autores principales: Brzezinka, Krzysztof, Nevedomskaya, Ekaterina, Lesche, Ralf, Haegebarth, Andrea, ter Laak, Antonius, Fernández-Montalván, Amaury E., Eberspaecher, Uwe, Werbeck, Nicolas D., Moenning, Ursula, Siegel, Stephan, Haendler, Bernard, Eheim, Ashley L., Stresemann, Carlo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016952/
https://www.ncbi.nlm.nih.gov/pubmed/31947537
http://dx.doi.org/10.3390/cancers12010201

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016952/
https://www.ncbi.nlm.nih.gov/pubmed/31947537
http://dx.doi.org/10.3390/cancers12010201

Ejemplares similares