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Characterization of the Menin-MLL Interaction as Therapeutic Cancer Target

Inhibiting the interaction of menin with the histone methyltransferase MLL1 (KMT2A) has recently emerged as a novel therapeutic strategy. Beneficial therapeutic effects have been postulated in leukemia, prostate, breast, liver and in synovial sarcoma models. In those indications, MLL1 recruitment by...

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Detalles Bibliográficos
Autores principales:	Brzezinka, Krzysztof, Nevedomskaya, Ekaterina, Lesche, Ralf, Haegebarth, Andrea, ter Laak, Antonius, Fernández-Montalván, Amaury E., Eberspaecher, Uwe, Werbeck, Nicolas D., Moenning, Ursula, Siegel, Stephan, Haendler, Bernard, Eheim, Ashley L., Stresemann, Carlo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016952/ https://www.ncbi.nlm.nih.gov/pubmed/31947537 http://dx.doi.org/10.3390/cancers12010201

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