Fibronectin in Cancer: Friend or Foe

The role of fibronectin (FN) in tumorigenesis and malignant progression has been highly controversial. Cancerous FN plays a tumor-suppressive role, whereas it is pro-metastatic and associated with poor prognosis. Interestingly, FN matrix deposited in the tumor microenvironments (TMEs) promotes tumor...

Descripción completa

Detalles Bibliográficos
Autores principales: Lin, Tsung-Cheng, Yang, Cheng-Han, Cheng, Li-Hsin, Chang, Wen-Tsan, Lin, Yuh-Rong, Cheng, Hung-Chi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016990/
https://www.ncbi.nlm.nih.gov/pubmed/31861892
http://dx.doi.org/10.3390/cells9010027
_version_ 1783497103095365632
author Lin, Tsung-Cheng
Yang, Cheng-Han
Cheng, Li-Hsin
Chang, Wen-Tsan
Lin, Yuh-Rong
Cheng, Hung-Chi
author_facet Lin, Tsung-Cheng
Yang, Cheng-Han
Cheng, Li-Hsin
Chang, Wen-Tsan
Lin, Yuh-Rong
Cheng, Hung-Chi
author_sort Lin, Tsung-Cheng
collection PubMed
description The role of fibronectin (FN) in tumorigenesis and malignant progression has been highly controversial. Cancerous FN plays a tumor-suppressive role, whereas it is pro-metastatic and associated with poor prognosis. Interestingly, FN matrix deposited in the tumor microenvironments (TMEs) promotes tumor progression but is paradoxically related to a better prognosis. Here, we justify how FN impacts tumor transformation and subsequently metastatic progression. Next, we try to reconcile and rationalize the seemingly conflicting roles of FN in cancer and TMEs. Finally, we propose future perspectives for potential FN-based therapeutic strategies.
format Online
Article
Text
id pubmed-7016990
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-70169902020-02-28 Fibronectin in Cancer: Friend or Foe Lin, Tsung-Cheng Yang, Cheng-Han Cheng, Li-Hsin Chang, Wen-Tsan Lin, Yuh-Rong Cheng, Hung-Chi Cells Review The role of fibronectin (FN) in tumorigenesis and malignant progression has been highly controversial. Cancerous FN plays a tumor-suppressive role, whereas it is pro-metastatic and associated with poor prognosis. Interestingly, FN matrix deposited in the tumor microenvironments (TMEs) promotes tumor progression but is paradoxically related to a better prognosis. Here, we justify how FN impacts tumor transformation and subsequently metastatic progression. Next, we try to reconcile and rationalize the seemingly conflicting roles of FN in cancer and TMEs. Finally, we propose future perspectives for potential FN-based therapeutic strategies. MDPI 2019-12-20 /pmc/articles/PMC7016990/ /pubmed/31861892 http://dx.doi.org/10.3390/cells9010027 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lin, Tsung-Cheng
Yang, Cheng-Han
Cheng, Li-Hsin
Chang, Wen-Tsan
Lin, Yuh-Rong
Cheng, Hung-Chi
Fibronectin in Cancer: Friend or Foe
title Fibronectin in Cancer: Friend or Foe
title_full Fibronectin in Cancer: Friend or Foe
title_fullStr Fibronectin in Cancer: Friend or Foe
title_full_unstemmed Fibronectin in Cancer: Friend or Foe
title_short Fibronectin in Cancer: Friend or Foe
title_sort fibronectin in cancer: friend or foe
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016990/
https://www.ncbi.nlm.nih.gov/pubmed/31861892
http://dx.doi.org/10.3390/cells9010027
work_keys_str_mv AT lintsungcheng fibronectinincancerfriendorfoe
AT yangchenghan fibronectinincancerfriendorfoe
AT chenglihsin fibronectinincancerfriendorfoe
AT changwentsan fibronectinincancerfriendorfoe
AT linyuhrong fibronectinincancerfriendorfoe
AT chenghungchi fibronectinincancerfriendorfoe

Ejemplares similares