Inhibition of the IL-18 Receptor Signaling Pathway Ameliorates Disease in a Murine Model of Rheumatoid Arthritis

Interleukin (IL)-18 expression in synovial tissue correlates with the severity of joint inflammation and the levels of pro-inflammatory cytokines. However, the role of the IL-18/IL-18 receptor-alpha (Rα) signaling pathway in autoimmune arthritis is unknown. Wild-type (WT) and IL-18Rα knockout (KO) m...

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Detalles Bibliográficos
Autores principales: Nozaki, Yuji, Ri, Jinhai, Sakai, Kenji, Niki, Kaoru, Kinoshita, Koji, Funauchi, Masanori, Matsumura, Itaru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7017073/
https://www.ncbi.nlm.nih.gov/pubmed/31861496
http://dx.doi.org/10.3390/cells9010011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7017073/
https://www.ncbi.nlm.nih.gov/pubmed/31861496
http://dx.doi.org/10.3390/cells9010011

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