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Origin of Monocytes/Macrophages Contributing to Chronic Inflammation in Chagas Disease: SIRT1 Inhibition of FAK-NFκB-Dependent Proliferation and Proinflammatory Activation of Macrophages

Background: Trypanosoma cruzi (Tc) causes Chagas disease (CD) that is the most frequent cause of heart failure in Latin America. TNF-α(+) monocytes/macrophages (Mo/Mφ) are associated with inflammatory pathology in chronic CD. In this study, we determined the progenitor lineage of Mo/Mφ contributing...

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Detalles Bibliográficos
Autores principales:	Wan, Xianxiu, Chowdhury, Imran Hussain, Jie, Zuliang, Choudhuri, Subhadip, Garg, Nisha Jain
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7017093/ https://www.ncbi.nlm.nih.gov/pubmed/31905606 http://dx.doi.org/10.3390/cells9010080

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