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Roles of CD38 in the Immune Response to Infection
CD38 is a multifunctional protein widely expressed in cells from the immune system and as a soluble form in biological fluids. CD38 expression is up-regulated by an array of inflammatory mediators, and it is frequently used as a cell activation marker. Studies in animal models indicate that CD38 fun...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7017097/ https://www.ncbi.nlm.nih.gov/pubmed/31963337 http://dx.doi.org/10.3390/cells9010228 |
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author | Glaría, Estibaliz Valledor, Annabel F. |
author_facet | Glaría, Estibaliz Valledor, Annabel F. |
author_sort | Glaría, Estibaliz |
collection | PubMed |
description | CD38 is a multifunctional protein widely expressed in cells from the immune system and as a soluble form in biological fluids. CD38 expression is up-regulated by an array of inflammatory mediators, and it is frequently used as a cell activation marker. Studies in animal models indicate that CD38 functional expression confers protection against infection by several bacterial and parasitic pathogens. In addition, infectious complications are associated with anti-CD38 immunotherapy. Although CD38 displays receptor and enzymatic activities that contribute to the establishment of an effective immune response, recent work raises the possibility that CD38 might also enhance the immunosuppressive potential of regulatory leukocytes. This review integrates the current knowledge on the diversity of functions mediated by CD38 in the host defense to infection. |
format | Online Article Text |
id | pubmed-7017097 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-70170972020-02-28 Roles of CD38 in the Immune Response to Infection Glaría, Estibaliz Valledor, Annabel F. Cells Review CD38 is a multifunctional protein widely expressed in cells from the immune system and as a soluble form in biological fluids. CD38 expression is up-regulated by an array of inflammatory mediators, and it is frequently used as a cell activation marker. Studies in animal models indicate that CD38 functional expression confers protection against infection by several bacterial and parasitic pathogens. In addition, infectious complications are associated with anti-CD38 immunotherapy. Although CD38 displays receptor and enzymatic activities that contribute to the establishment of an effective immune response, recent work raises the possibility that CD38 might also enhance the immunosuppressive potential of regulatory leukocytes. This review integrates the current knowledge on the diversity of functions mediated by CD38 in the host defense to infection. MDPI 2020-01-16 /pmc/articles/PMC7017097/ /pubmed/31963337 http://dx.doi.org/10.3390/cells9010228 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Glaría, Estibaliz Valledor, Annabel F. Roles of CD38 in the Immune Response to Infection |
title | Roles of CD38 in the Immune Response to Infection |
title_full | Roles of CD38 in the Immune Response to Infection |
title_fullStr | Roles of CD38 in the Immune Response to Infection |
title_full_unstemmed | Roles of CD38 in the Immune Response to Infection |
title_short | Roles of CD38 in the Immune Response to Infection |
title_sort | roles of cd38 in the immune response to infection |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7017097/ https://www.ncbi.nlm.nih.gov/pubmed/31963337 http://dx.doi.org/10.3390/cells9010228 |
work_keys_str_mv | AT glariaestibaliz rolesofcd38intheimmuneresponsetoinfection AT valledorannabelf rolesofcd38intheimmuneresponsetoinfection |