Cargando…

Mitochondrial Fusion Via OPA1 and MFN1 Supports Liver Tumor Cell Metabolism and Growth

Metabolic reprogramming universally occurs in cancer. Mitochondria act as the hubs of bioenergetics and metabolism. The morphodynamics of mitochondria, comprised of fusion and fission processes, are closely associated with mitochondrial functions and are often dysregulated in cancer. In this study,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Meng, Wang, Ling, Wang, Yijin, Zhang, Shaoshi, Zhou, Guoying, Lieshout, Ruby, Ma, Buyun, Liu, Jiaye, Qu, Changbo, Verstegen, Monique M. A., Sprengers, Dave, Kwekkeboom, Jaap, van der Laan, Luc J. W., Cao, Wanlu, Peppelenbosch, Maikel P., Pan, Qiuwei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7017104/ https://www.ncbi.nlm.nih.gov/pubmed/31947947 http://dx.doi.org/10.3390/cells9010121

Ejemplares similares

Dichotomal functions of phosphorylated and unphosphorylated STAT1 in hepatocellular carcinoma
por: Ma, Buyun, et al.
Publicado: (2018)

LGR5 marks targetable tumor-initiating cells in mouse liver cancer
por: Cao, Wanlu, et al.
Publicado: (2020)

Cancer-Associated Fibroblasts Provide a Stromal Niche for Liver Cancer Organoids That Confers Trophic Effects and Therapy Resistance
por: Liu, Jiaye, et al.
Publicado: (2020)

Mitochondria in the biology, pathogenesis, and treatment of hepatitis virus infections
por: Qu, Changbo, et al.
Publicado: (2019)

TIGIT, the Next Step Towards Successful Combination Immune Checkpoint Therapy in Cancer
por: Ge, Zhouhong, et al.
Publicado: (2021)

Direct‐acting antiviral agents for liver transplant recipients with recurrent genotype 1 hepatitis C virus infection: Systematic review and meta‐analysis
por: Liu, Jiaye, et al.
Publicado: (2019)

The biological process of lysine‐tRNA charging is therapeutically targetable in liver cancer
por: Zhang, Ruyi, et al.
Publicado: (2020)

Kinome profiling of cholangiocarcinoma organoids reveals potential druggable targets that hold promise for treatment stratification
por: Lieshout, Ruby, et al.
Publicado: (2022)

Estimating the Global Prevalence, Disease Progression, and Clinical Outcome of Hepatitis Delta Virus Infection
por: Miao, Zhijiang, et al.
Publicado: (2020)

TIGIT and PD1 Co-blockade Restores ex vivo Functions of Human Tumor-Infiltrating CD8(+) T Cells in Hepatocellular Carcinoma
por: Ge, Zhouhong, et al.
Publicado: (2021)

Factors associated with ethnical disparity in overall survival for patients with hepatocellular carcinoma
por: Li, Juan, et al.
Publicado: (2017)

Recombinant identification, molecular classification and proposed reference genomes for hepatitis delta virus
por: Miao, Zhijiang, et al.
Publicado: (2018)

Modelling immune cytotoxicity for cholangiocarcinoma with tumour-derived organoids and effector T cells
por: Zhou, Guoying, et al.
Publicado: (2022)

Detection of oncogenic mutations in paired circulating tumor DNA and circulating tumor cells in patients with hepatocellular carcinoma
por: Ge, Zhouhong, et al.
Publicado: (2021)

Camrelizumab—targeting a novel PD-1 epitope to treat hepatocellular carcinoma
por: Rakké, Yannick Sebastiaan, et al.
Publicado: (2020)

T-cell suppression mediated by regulatory T cells infiltrating hepatic tumors can be overcome by GITRL treatment
por: Pedroza-Gonzalez, Alexander, et al.
Publicado: (2013)

Nucleoside analogue 2’-C-methylcytidine inhibits hepatitis E virus replication but antagonizes ribavirin
por: Qu, Changbo, et al.
Publicado: (2017)

Estimating Global Epidemiology of Low-Pathogenic Human Coronaviruses in Relation to the COVID-19 Context
por: Li, Pengfei, et al.
Publicado: (2020)

The global epidemiology of hepatitis E virus infection: A systematic review and meta‐analysis
por: Li, Pengfei, et al.
Publicado: (2020)

Recapitulating hepatitis E virus–host interactions and facilitating antiviral drug discovery in human liver–derived organoids
por: Li, Pengfei, et al.
Publicado: (2022)

Rotavirus Infection and Cytopathogenesis in Human Biliary Organoids Potentially Recapitulate Biliary Atresia Development
por: Chen, Sunrui, et al.
Publicado: (2020)

Blocking Wnt Secretion Reduces Growth of Hepatocellular Carcinoma Cell Lines Mostly Independent of β-Catenin Signaling()
por: Wang, Wenhui, et al.
Publicado: (2016)

Emerging organoid-immune co-culture models for cancer research: from oncoimmunology to personalized immunotherapies
por: Magré, Luc, et al.
Publicado: (2023)

The Mitochondrial Fusion-Related Proteins Mfn2 and OPA1 are Transcriptionally Induced during Differentiation of Bone Marrow Progenitors to Immature Dendritic Cells
por: Ryu, Seung-Wook, et al.
Publicado: (2015)

MFN1 and MFN2 Are Dispensable for Sperm Development and Functions in Mice
por: Miao, Junru, et al.
Publicado: (2021)

The BCL-2–like protein CED-9 of C. elegans promotes FZO-1/Mfn1,2– and EAT-3/Opa1–dependent mitochondrial fusion
por: Rolland, Stéphane G., et al.
Publicado: (2009)

The MFN1 and MFN2 mitofusins promote clustering between mitochondria and peroxisomes
por: Huo, Yinbo, et al.
Publicado: (2022)

Convergent Transcription of Interferon-stimulated Genes by TNF-α and IFN-α Augments Antiviral Activity against HCV and HEV
por: Wang, Wenshi, et al.
Publicado: (2016)

Letter to the Editor: High Mobility Group Box Protein 1 Release Is an Identified Driver of Inflammation in the Pathogenesis of Biliary Atresia
por: Shi, Shaojun, et al.
Publicado: (2021)

Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development
por: Chen, Hsiuchen, et al.
Publicado: (2003)

Hearts deficient in both Mfn1 and Mfn2 are protected against acute myocardial infarction
por: Hall, A R, et al.
Publicado: (2016)

MFN2 Plays a Distinct Role from MFN1 in Regulating Spermatogonial Differentiation
por: Chen, Wei, et al.
Publicado: (2020)

Identification of a mitofusin specificity region that confers unique activities to Mfn1 and Mfn2
por: Sloat, S. R., et al.
Publicado: (2019)

6-Thioguanine inhibits rotavirus replication through suppression of Rac1 GDP/GTP cycling
por: Yin, Yuebang, et al.
Publicado: (2018)

PI3K-Akt-mTOR axis sustains rotavirus infection via the 4E-BP1 mediated autophagy pathway and represents an antiviral target
por: Yin, Yuebang, et al.
Publicado: (2017)

Potential association between COVID-19 mortality and health-care resource availability
por: Ji, Yunpeng, et al.
Publicado: (2020)

Inhibition of hepatitis E virus replication by proteasome inhibitor is nonspecific
por: Xu, Lei, et al.
Publicado: (2014)

Deciphering Tumour Microenvironment of Liver Cancer through Deconvolution of Bulk RNA-Seq Data with Single-Cell Atlas
por: Zhang, Shaoshi, et al.
Publicado: (2022)

Mitochondrial Dynamics Related Genes -MFN1, MFN2 and DRP1 Polymorphisms are Associated with Risk of Lung Cancer
por: Liang, Xiaohua, et al.
Publicado: (2021)

Correction: Hearts deficient in both Mfn1 and Mfn2 are protected against acute myocardial infarction
por: Hall, A. R., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_ugce1asfmbkiig17nsf9um5erc