Inhibition of PP2A with LB-100 Enhances Efficacy of CAR-T Cell Therapy Against Glioblastoma

Chimeric antigen receptor (CAR)-engineered T cells represent a promising modality for treating glioblastoma. Recently, we demonstrated that CAR-T cells targeting carbonic anhydrase IX (CAIX), a protein involved in HIF-1a hypoxic signaling, is a promising CAR-T cell target in an intracranial murine g...

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Detalles Bibliográficos
Autores principales: Cui, Jing, Wang, Herui, Medina, Rogelio, Zhang, Qi, Xu, Chen, Indig, Iris H., Zhou, Jingcheng, Song, Qi, Dmitriev, Pauline, Sun, Mitchell Y., Guo, Liemei, Wang, Yang, Rosenblum, Jared S., Kovach, John S., Gilbert, Mark R., Zhuang, Zhengping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7017120/
https://www.ncbi.nlm.nih.gov/pubmed/31935881
http://dx.doi.org/10.3390/cancers12010139

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