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PP2A Deficiency Enhances Carcinogenesis of Lgr5(+) Intestinal Stem Cells Both in Organoids and In Vivo

In most cancers, cellular origin and the contribution of intrinsic and extrinsic factors toward transformation remain elusive. Cell specific carcinogenesis models are currently unavailable. To investigate cellular origin in carcinogenesis, we developed a tumorigenesis model based on a combination of...

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Detalles Bibliográficos
Autores principales:	Yen, Yu-Ting, Chien, May, Lai, Yung-Chih, Chen, Dao-Peng, Chuong, Cheng-Ming, Hung, Mien-Chie, Hung, Shih-Chieh
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7017129/ https://www.ncbi.nlm.nih.gov/pubmed/31905853 http://dx.doi.org/10.3390/cells9010090

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