Cargando…

Protein Kinase B Inactivation Is Associated with Magnolol-Enhanced Therapeutic Efficacy of Sorafenib in Hepatocellular Carcinoma In Vitro and In Vivo

Although sorafenib, an oral multikinase inhibitor, was approved as a treatment drug of advance hepatocellular carcinoma (HCC), treatment efficacy still requires improvement. Searching for the adjuvant reagent for enhancing sorafenib efficacy remains as a critical issue. Sorafenib has been proved to...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Jiann-Hwa, Chiang, I-Tsang, Hsu, Fei-Ting
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7017147/ https://www.ncbi.nlm.nih.gov/pubmed/31905887 http://dx.doi.org/10.3390/cancers12010087

Ejemplares similares

Induction of Apoptosis, Inhibition of MCL-1, and VEGF-A Expression Are Associated with the Anti-Cancer Efficacy of Magnolol Combined with Regorafenib in Hepatocellular Carcinoma
por: Chen, Cheng-Hsien, et al.
Publicado: (2021)

Suppression of PKCδ/NF-κB Signaling and Apoptosis Induction through Extrinsic/Intrinsic Pathways Are Associated with Magnolol-Inhibited Tumor Progression in Colorectal Cancer In Vitro and In Vivo
por: Su, Chun-Min, et al.
Publicado: (2020)

The Protective Effect of Magnolol in Osteoarthritis: In vitro and in vivo Studies
por: Hu, Zhi-Chao, et al.
Publicado: (2019)

Synergistic Effect of Sorafenib and Radiation on Human Oral Carcinoma in vivo
por: Hsu, Fei-Ting, et al.
Publicado: (2015)

CYP3A Excipient-Based Microemulsion Prolongs the Effect of Magnolol on Ischemia Stroke Rats
por: Guo, Jiun-Wen, et al.
Publicado: (2020)

Magnolol Ameliorates Ligature-Induced Periodontitis in Rats and Osteoclastogenesis: In Vivo and In Vitro Study
por: Lu, Sheng-Hua, et al.
Publicado: (2013)

Therapeutic Effects of Crocin Alone or in Combination with Sorafenib against Hepatocellular Carcinoma: In Vivo & In Vitro Insights
por: Abdu, Suzan, et al.
Publicado: (2022)

Protein Kinase B and Extracellular Signal-Regulated Kinase Inactivation is Associated with Regorafenib-Induced Inhibition of Osteosarcoma Progression In Vitro and In Vivo
por: Pan, Po-Jung, et al.
Publicado: (2019)

Improving the Therapeutic Efficacy of Sorafenib for Hepatocellular Carcinoma by Repurposing Disulfiram
por: Zhang, Gong, et al.
Publicado: (2022)

In vitro inhibitory activities of magnolol against Candida spp.
por: Zhou, Peiru, et al.
Publicado: (2017)

Synthesized Magnolol Derivatives Improve Anti-Micropterus salmoides Rhabdovirus (MSRV) Activity In Vivo
por: Jin, Yingjie, et al.
Publicado: (2022)

Semi-Synthesis and In Vitro Anti-Cancer Evaluation of Magnolol Derivatives
por: Sun, Xiao-Long, et al.
Publicado: (2021)

In silico and in vitro identification of inhibitory activities of sorafenib on histone deacetylases in hepatocellular carcinoma cells
por: Liu, Tsang-Pai, et al.
Publicado: (2017)

Tumor Treating Fields (TTFields) Concomitant with Sorafenib Inhibit Hepatocellular Carcinoma In Vitro and In Vivo
por: Davidi, Shiri, et al.
Publicado: (2022)

Effects of Sorafenib and Quercetin Alone or in Combination in Treating Hepatocellular Carcinoma: In Vitro and In Vivo Approaches
por: Abdu, Suzan, et al.
Publicado: (2022)

Insights on the Multifunctional Activities of Magnolol
por: Zhang, Jianhong, et al.
Publicado: (2019)

Inactivation of Transcriptional Repressor Capicua Confers Sorafenib Resistance in Human Hepatocellular Carcinoma
por: Hashiba, Tomomi, et al.
Publicado: (2020)

Safety and efficacy of sorafenib in the treatment of hepatocellular carcinoma
por: Almhanna, Khaldoun, et al.
Publicado: (2009)

Magnolol Suppresses Pancreatic Cancer Development In Vivo and In Vitro via Negatively Regulating TGF-β/Smad Signaling
por: Chen, Shuo, et al.
Publicado: (2020)

Quantitative analysis of the therapeutic effect of magnolol on MPTP-induced mouse model of Parkinson’s disease using in vivo (18)F-9-fluoropropyl-(+)-dihydrotetrabenazine PET imaging
por: Weng, Chi-Chang, et al.
Publicado: (2017)

Magnolol inhibits venous remodeling in mice
por: Kuk, Hanna, et al.
Publicado: (2017)

Honokiol and Magnolol: Insights into Their Antidermatophytic Effects
por: Trifan, Adriana, et al.
Publicado: (2021)

Efficacy of Sorafenib Monotherapy versus Sorafenib-Based Loco-Regional Treatments in Advanced Hepatocellular Carcinoma
por: Lee, Sangheun, et al.
Publicado: (2013)

Study of RNA Interference Targeting NET-1 Combination with Sorafenib for Hepatocellular Carcinoma Therapy In Vitro and In Vivo
por: He, Song, et al.
Publicado: (2013)

Exosomes derived from HCC cells induce sorafenib resistance in hepatocellular carcinoma both in vivo and in vitro
por: Qu, Zhen, et al.
Publicado: (2016)

Tenofovir Hampers the Efficacy of Sorafenib in Prolonging Overall Survival in Hepatocellular Carcinoma
por: Liang, Kung-Hao, et al.
Publicado: (2021)

Synergistic effects of autophagy/mitophagy inhibitors and magnolol promote apoptosis and antitumor efficacy
por: Tang, Yancheng, et al.
Publicado: (2021)

Magnolol Protects against MPTP/MPP(+)-Induced Toxicity via Inhibition of Oxidative Stress in In Vivo and In Vitro Models of Parkinson's Disease
por: Muroyama, Akiko, et al.
Publicado: (2012)

Involvement of HO-1 and Autophagy in the Protective Effect of Magnolol in Hepatic Steatosis-Induced NLRP3 Inflammasome Activation In Vivo and In Vitro
por: Kuo, Ni-Chun, et al.
Publicado: (2020)

Design, synthesis and biological evaluation of a novel colchicine-magnolol hybrid for inhibiting the growth of Lewis lung carcinoma in Vitro and in Vivo
por: Li, Zhiyue, et al.
Publicado: (2022)

Magnolol Induces the Extrinsic/Intrinsic Apoptosis Pathways and Inhibits STAT3 Signaling-Mediated Invasion of Glioblastoma Cells
por: Yueh, Po-Fu, et al.
Publicado: (2021)

Pharmacology, Toxicity, Bioavailability, and Formulation of Magnolol: An Update
por: Lin, Yiping, et al.
Publicado: (2021)

Synthesis, anti-aging and mechanism of magnolol derivatives
por: Pang, Xinxin, et al.
Publicado: (2023)

The safety and efficacy of transarterial chemoembolization combined with sorafenib and sorafenib mono-therapy in patients with BCLC stage B/C hepatocellular carcinoma
por: Wu, Fei-Xiang, et al.
Publicado: (2017)

Efficacy of Sorafenib for the Treatment of Post-Transplant Hepatocellular Carcinoma Recurrence
por: Kang, Seong Hee, et al.
Publicado: (2018)

Synergistic anti-tumor efficacy of sorafenib and fluvastatin in hepatocellular carcinoma
por: Cheng, Yang, et al.
Publicado: (2017)

Efficacy and safety of sorafenib in elderly patients with advanced hepatocellular carcinoma
por: Marta, Guilherme Nader, et al.
Publicado: (2021)

Targeting DNA repair to enhance the efficacy of sorafenib in hepatocellular carcinoma
por: Samadaei, Mahzeiar, et al.
Publicado: (2022)

Kaempferol-Mediated Sensitization Enhances Chemotherapeutic Efficacy of Sorafenib Against Hepatocellular Carcinoma: An In Silico and In Vitro Approach
por: Nair, Bhagyalakshmi, et al.
Publicado: (2020)

Novel FLT3/AURK multikinase inhibitor is efficacious against sorafenib-refractory and sorafenib-resistant hepatocellular carcinoma
por: Lai, You-Liang, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_dv67pcikud2bhtrdqmqc5thpaf