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Protein Oxidative Damage in UV-Related Skin Cancer and Dysplastic Lesions Contributes to Neoplastic Promotion and Progression
The ultraviolet (UV) component of solar radiation is the major driving force of skin carcinogenesis. Most of studies on UV carcinogenesis actually focus on DNA damage while their proteome-damaging ability and its contribution to skin carcinogenesis have remained largely underexplored. A redox proteo...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7017152/ https://www.ncbi.nlm.nih.gov/pubmed/31906275 http://dx.doi.org/10.3390/cancers12010110 |
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author | Tramutola, Antonella Falcucci, Susanna Brocco, Umberto Triani, Francesca Lanzillotta, Chiara Donati, Michele Panetta, Chiara Luzi, Fabiola Iavarone, Federica Vincenzoni, Federica Castagnola, Massimo Perluigi, Marzia Di Domenico, Fabio De Marco, Federico |
author_facet | Tramutola, Antonella Falcucci, Susanna Brocco, Umberto Triani, Francesca Lanzillotta, Chiara Donati, Michele Panetta, Chiara Luzi, Fabiola Iavarone, Federica Vincenzoni, Federica Castagnola, Massimo Perluigi, Marzia Di Domenico, Fabio De Marco, Federico |
author_sort | Tramutola, Antonella |
collection | PubMed |
description | The ultraviolet (UV) component of solar radiation is the major driving force of skin carcinogenesis. Most of studies on UV carcinogenesis actually focus on DNA damage while their proteome-damaging ability and its contribution to skin carcinogenesis have remained largely underexplored. A redox proteomic analysis of oxidized proteins in solar-induced neoplastic skin lesion and perilesional areas has been conducted showing that the protein oxidative burden mostly concerns a selected number of proteins participating to a defined set of functions, namely: chaperoning and stress response; protein folding/refolding and protein quality control; proteasomal function; DNA damage repair; protein- and vesicle-trafficking; cell architecture, adhesion/extra-cellular matrix (ECM) interaction; proliferation/oncosuppression; apoptosis/survival, all of them ultimately concurring either to structural damage repair or to damage detoxication and stress response. In peri-neoplastic areas the oxidative alterations are conducive to the persistence of genetic alterations, dysfunctional apoptosis surveillance, and a disrupted extracellular environment, thus creating the condition for transformant clones to establish, expand and progress. A comparatively lower burden of oxidative damage is observed in neoplastic areas. Such a finding can reflect an adaptive selection of best fitting clones to the sharply pro-oxidant neoplastic environment. In this context the DNA damage response appears severely perturbed, thus sustaining an increased genomic instability and an accelerated rate of neoplastic evolution. In conclusion UV radiation, in addition to being a cancer-initiating agent, can act, through protein oxidation, as a cancer-promoting agent and as an inducer of genomic instability concurring with the neoplastic progression of established lesions. |
format | Online Article Text |
id | pubmed-7017152 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-70171522020-02-28 Protein Oxidative Damage in UV-Related Skin Cancer and Dysplastic Lesions Contributes to Neoplastic Promotion and Progression Tramutola, Antonella Falcucci, Susanna Brocco, Umberto Triani, Francesca Lanzillotta, Chiara Donati, Michele Panetta, Chiara Luzi, Fabiola Iavarone, Federica Vincenzoni, Federica Castagnola, Massimo Perluigi, Marzia Di Domenico, Fabio De Marco, Federico Cancers (Basel) Article The ultraviolet (UV) component of solar radiation is the major driving force of skin carcinogenesis. Most of studies on UV carcinogenesis actually focus on DNA damage while their proteome-damaging ability and its contribution to skin carcinogenesis have remained largely underexplored. A redox proteomic analysis of oxidized proteins in solar-induced neoplastic skin lesion and perilesional areas has been conducted showing that the protein oxidative burden mostly concerns a selected number of proteins participating to a defined set of functions, namely: chaperoning and stress response; protein folding/refolding and protein quality control; proteasomal function; DNA damage repair; protein- and vesicle-trafficking; cell architecture, adhesion/extra-cellular matrix (ECM) interaction; proliferation/oncosuppression; apoptosis/survival, all of them ultimately concurring either to structural damage repair or to damage detoxication and stress response. In peri-neoplastic areas the oxidative alterations are conducive to the persistence of genetic alterations, dysfunctional apoptosis surveillance, and a disrupted extracellular environment, thus creating the condition for transformant clones to establish, expand and progress. A comparatively lower burden of oxidative damage is observed in neoplastic areas. Such a finding can reflect an adaptive selection of best fitting clones to the sharply pro-oxidant neoplastic environment. In this context the DNA damage response appears severely perturbed, thus sustaining an increased genomic instability and an accelerated rate of neoplastic evolution. In conclusion UV radiation, in addition to being a cancer-initiating agent, can act, through protein oxidation, as a cancer-promoting agent and as an inducer of genomic instability concurring with the neoplastic progression of established lesions. MDPI 2020-01-01 /pmc/articles/PMC7017152/ /pubmed/31906275 http://dx.doi.org/10.3390/cancers12010110 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Tramutola, Antonella Falcucci, Susanna Brocco, Umberto Triani, Francesca Lanzillotta, Chiara Donati, Michele Panetta, Chiara Luzi, Fabiola Iavarone, Federica Vincenzoni, Federica Castagnola, Massimo Perluigi, Marzia Di Domenico, Fabio De Marco, Federico Protein Oxidative Damage in UV-Related Skin Cancer and Dysplastic Lesions Contributes to Neoplastic Promotion and Progression |
title | Protein Oxidative Damage in UV-Related Skin Cancer and Dysplastic Lesions Contributes to Neoplastic Promotion and Progression |
title_full | Protein Oxidative Damage in UV-Related Skin Cancer and Dysplastic Lesions Contributes to Neoplastic Promotion and Progression |
title_fullStr | Protein Oxidative Damage in UV-Related Skin Cancer and Dysplastic Lesions Contributes to Neoplastic Promotion and Progression |
title_full_unstemmed | Protein Oxidative Damage in UV-Related Skin Cancer and Dysplastic Lesions Contributes to Neoplastic Promotion and Progression |
title_short | Protein Oxidative Damage in UV-Related Skin Cancer and Dysplastic Lesions Contributes to Neoplastic Promotion and Progression |
title_sort | protein oxidative damage in uv-related skin cancer and dysplastic lesions contributes to neoplastic promotion and progression |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7017152/ https://www.ncbi.nlm.nih.gov/pubmed/31906275 http://dx.doi.org/10.3390/cancers12010110 |
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