The Role of E3, E4 Ubiquitin Ligase (UBE4B) in Human Pathologies

The genome is exposed daily to many deleterious factors. Ubiquitination is a mechanism that regulates several crucial cellular functions, allowing cells to react upon various stimuli in order to preserve their homeostasis. Ubiquitin ligases act as specific regulators and actively participate among o...

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Autores principales: Antoniou, Nikolaos, Lagopati, Nefeli, Balourdas, Dimitrios Ilias, Nikolaou, Michail, Papalampros, Alexandros, Vasileiou, Panagiotis V. S., Myrianthopoulos, Vassilios, Kotsinas, Athanassios, Shiloh, Yosef, Liontos, Michalis, Gorgoulis, Vassilis G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7017255/
https://www.ncbi.nlm.nih.gov/pubmed/31878315
http://dx.doi.org/10.3390/cancers12010062
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author Antoniou, Nikolaos
Lagopati, Nefeli
Balourdas, Dimitrios Ilias
Nikolaou, Michail
Papalampros, Alexandros
Vasileiou, Panagiotis V. S.
Myrianthopoulos, Vassilios
Kotsinas, Athanassios
Shiloh, Yosef
Liontos, Michalis
Gorgoulis, Vassilis G.
author_facet Antoniou, Nikolaos
Lagopati, Nefeli
Balourdas, Dimitrios Ilias
Nikolaou, Michail
Papalampros, Alexandros
Vasileiou, Panagiotis V. S.
Myrianthopoulos, Vassilios
Kotsinas, Athanassios
Shiloh, Yosef
Liontos, Michalis
Gorgoulis, Vassilis G.
author_sort Antoniou, Nikolaos
collection PubMed
description The genome is exposed daily to many deleterious factors. Ubiquitination is a mechanism that regulates several crucial cellular functions, allowing cells to react upon various stimuli in order to preserve their homeostasis. Ubiquitin ligases act as specific regulators and actively participate among others in the DNA damage response (DDR) network. UBE4B is a newly identified member of E3 ubiquitin ligases that appears to be overexpressed in several human neoplasms. The aim of this review is to provide insights into the role of UBE4B ubiquitin ligase in DDR and its association with p53 expression, shedding light particularly on the molecular mechanisms of carcinogenesis.
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spelling pubmed-70172552020-02-28 The Role of E3, E4 Ubiquitin Ligase (UBE4B) in Human Pathologies Antoniou, Nikolaos Lagopati, Nefeli Balourdas, Dimitrios Ilias Nikolaou, Michail Papalampros, Alexandros Vasileiou, Panagiotis V. S. Myrianthopoulos, Vassilios Kotsinas, Athanassios Shiloh, Yosef Liontos, Michalis Gorgoulis, Vassilis G. Cancers (Basel) Review The genome is exposed daily to many deleterious factors. Ubiquitination is a mechanism that regulates several crucial cellular functions, allowing cells to react upon various stimuli in order to preserve their homeostasis. Ubiquitin ligases act as specific regulators and actively participate among others in the DNA damage response (DDR) network. UBE4B is a newly identified member of E3 ubiquitin ligases that appears to be overexpressed in several human neoplasms. The aim of this review is to provide insights into the role of UBE4B ubiquitin ligase in DDR and its association with p53 expression, shedding light particularly on the molecular mechanisms of carcinogenesis. MDPI 2019-12-24 /pmc/articles/PMC7017255/ /pubmed/31878315 http://dx.doi.org/10.3390/cancers12010062 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Antoniou, Nikolaos
Lagopati, Nefeli
Balourdas, Dimitrios Ilias
Nikolaou, Michail
Papalampros, Alexandros
Vasileiou, Panagiotis V. S.
Myrianthopoulos, Vassilios
Kotsinas, Athanassios
Shiloh, Yosef
Liontos, Michalis
Gorgoulis, Vassilis G.
The Role of E3, E4 Ubiquitin Ligase (UBE4B) in Human Pathologies
title The Role of E3, E4 Ubiquitin Ligase (UBE4B) in Human Pathologies
title_full The Role of E3, E4 Ubiquitin Ligase (UBE4B) in Human Pathologies
title_fullStr The Role of E3, E4 Ubiquitin Ligase (UBE4B) in Human Pathologies
title_full_unstemmed The Role of E3, E4 Ubiquitin Ligase (UBE4B) in Human Pathologies
title_short The Role of E3, E4 Ubiquitin Ligase (UBE4B) in Human Pathologies
title_sort role of e3, e4 ubiquitin ligase (ube4b) in human pathologies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7017255/
https://www.ncbi.nlm.nih.gov/pubmed/31878315
http://dx.doi.org/10.3390/cancers12010062
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