Monitoring Therapy Efficiency in Cancer through Extracellular Vesicles

Extracellular vesicles (EVs) are a heterogeneous group of membrane-enclosed vesicles made of a phospholipid bilayer and are secreted by all cell types. EVs are present in a variety of body fluids containing proteins, DNA, RNA species, and lipids, and play an important role in cell- to-cell communica...

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Detalles Bibliográficos
Autores principales: Stevic, Ines, Buescher, Gustav, Ricklefs, Franz Lennard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7017260/
https://www.ncbi.nlm.nih.gov/pubmed/31935901
http://dx.doi.org/10.3390/cells9010130
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author Stevic, Ines
Buescher, Gustav
Ricklefs, Franz Lennard
author_facet Stevic, Ines
Buescher, Gustav
Ricklefs, Franz Lennard
author_sort Stevic, Ines
collection PubMed
description Extracellular vesicles (EVs) are a heterogeneous group of membrane-enclosed vesicles made of a phospholipid bilayer and are secreted by all cell types. EVs are present in a variety of body fluids containing proteins, DNA, RNA species, and lipids, and play an important role in cell- to-cell communication and are worth being considered as biomarkers for both early diagnosis of cancer patients and real-time monitoring of treatment response. Recently, emerging evidence verified EVs to have crucial roles in cancer progression and metastasis and a great potential in therapeutic applications. In this review, we discuss the potential of EVs in monitoring the efficacy of cancer therapies.
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spelling pubmed-70172602020-02-28 Monitoring Therapy Efficiency in Cancer through Extracellular Vesicles Stevic, Ines Buescher, Gustav Ricklefs, Franz Lennard Cells Review Extracellular vesicles (EVs) are a heterogeneous group of membrane-enclosed vesicles made of a phospholipid bilayer and are secreted by all cell types. EVs are present in a variety of body fluids containing proteins, DNA, RNA species, and lipids, and play an important role in cell- to-cell communication and are worth being considered as biomarkers for both early diagnosis of cancer patients and real-time monitoring of treatment response. Recently, emerging evidence verified EVs to have crucial roles in cancer progression and metastasis and a great potential in therapeutic applications. In this review, we discuss the potential of EVs in monitoring the efficacy of cancer therapies. MDPI 2020-01-06 /pmc/articles/PMC7017260/ /pubmed/31935901 http://dx.doi.org/10.3390/cells9010130 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Stevic, Ines
Buescher, Gustav
Ricklefs, Franz Lennard
Monitoring Therapy Efficiency in Cancer through Extracellular Vesicles
title Monitoring Therapy Efficiency in Cancer through Extracellular Vesicles
title_full Monitoring Therapy Efficiency in Cancer through Extracellular Vesicles
title_fullStr Monitoring Therapy Efficiency in Cancer through Extracellular Vesicles
title_full_unstemmed Monitoring Therapy Efficiency in Cancer through Extracellular Vesicles
title_short Monitoring Therapy Efficiency in Cancer through Extracellular Vesicles
title_sort monitoring therapy efficiency in cancer through extracellular vesicles
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7017260/
https://www.ncbi.nlm.nih.gov/pubmed/31935901
http://dx.doi.org/10.3390/cells9010130
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