Cargando…

Prevention of DNA Replication Stress by CHK1 Leads to Chemoresistance Despite a DNA Repair Defect in Homologous Recombination in Breast Cancer

Chromosomal instability not only has a negative effect on survival in triple-negative breast cancer, but also on the well treatable subgroup of luminal A tumors. This suggests a general mechanism independent of subtypes. Increased chromosomal instability (CIN) in triple-negative breast cancer (TNBC)...

Descripción completa

Detalles Bibliográficos
Autores principales:	Meyer, Felix, Becker, Saskia, Classen, Sandra, Parplys, Ann Christin, Mansour, Wael Yassin, Riepen, Britta, Timm, Sara, Ruebe, Claudia, Jasin, Maria, Wikman, Harriet, Petersen, Cordula, Rothkamm, Kai, Borgmann, Kerstin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7017274/ https://www.ncbi.nlm.nih.gov/pubmed/31963582 http://dx.doi.org/10.3390/cells9010238

Ejemplares similares

Exploiting Chromosomal Instability of PTEN-Deficient Triple-Negative Breast Cancer Cell Lines for the Sensitization Against PARP1 Inhibition in a Replication-Dependent Manner
por: Rieckhoff, Johanna, et al.
Publicado: (2020)

Crosstalk between immune checkpoint and DNA damage response inhibitors for radiosensitization of tumors
por: Classen, Sandra, et al.
Publicado: (2023)

PARP1 inhibition radiosensitizes HNSCC cells deficient in homologous recombination by disabling the DNA replication fork elongation response
por: Wurster, Stephanie, et al.
Publicado: (2016)

Efficient DNA Repair Mitigates Replication Stress Resulting in Less Immunogenic Cytosolic DNA in Radioresistant Breast Cancer Stem Cells
por: Meyer, Felix, et al.
Publicado: (2022)

Increased replication stress and R-loop accumulation in EGFRvIII-expressing glioblastoma present new therapeutic opportunities
por: Struve, Nina, et al.
Publicado: (2021)

Heterozygous mutations in PALB2 cause DNA replication and damage response defects
por: Nikkilä, Jenni, et al.
Publicado: (2013)

Partial Reduction in BRCA1 Gene Dose Modulates DNA Replication Stress Level and Thereby Contributes to Sensitivity or Resistance
por: Classen, Sandra, et al.
Publicado: (2022)

A Lack of Effectiveness in the ATM-Orchestrated DNA Damage Response Contributes to the DNA Repair Defect of HPV-Positive Head and Neck Cancer Cells
por: Köcher, Sabrina, et al.
Publicado: (2022)

Ubiquitination of the DNA-damage checkpoint kinase CHK1 by TRAF4 is required for CHK1 activation
por: Yu, Xinfang, et al.
Publicado: (2020)

CHK2 kinase in the DNA damage response and beyond
por: Zannini, Laura, et al.
Publicado: (2014)

MEDB-50. Assessment of cellular radiosensitivity and DNA repair in medulloblastoma cell lines and patient-derivded xenograft slice cultures
por: Feyerabend, Simon, et al.
Publicado: (2022)

DNA Damage Response during Replication Correlates with CIN70 Score and Determines Survival in HNSCC Patients
por: Bold, Ioan T., et al.
Publicado: (2021)

Impaired 53BP1/RIF1 DSB mediated end-protection stimulates CtIP-dependent end resection and switches the repair to PARP1-dependent end joining in G1
por: Bakr, Ali, et al.
Publicado: (2016)

The DNA repair component Metnase regulates Chk1 stability
por: Williamson, Elizabeth A, et al.
Publicado: (2014)

PAK6 promotes homologous-recombination to enhance chemoresistance to oxaliplatin through ATR/CHK1 signaling in gastric cancer
por: Huang, Weicai, et al.
Publicado: (2022)

Radiosensitization of HNSCC cells by EGFR inhibition depends on the induction of cell cycle arrests
por: Kriegs, Malte, et al.
Publicado: (2016)

Cdc45 is limiting for replication initiation in humans
por: Köhler, Carsten, et al.
Publicado: (2016)

G2 checkpoint targeting via Wee1 inhibition radiosensitizes EGFRvIII-positive glioblastoma cells
por: Cetin, Meryem H., et al.
Publicado: (2023)

DNA polymerase κ-dependent DNA synthesis at stalled replication forks is important for CHK1 activation
por: Bétous, Rémy, et al.
Publicado: (2013)

Chk1, Chk2, is the amplifier on?
por: Dove, Alan W.
Publicado: (2001)

Regulated Degradation of Chk1 by chaperone-mediated autophagy in response to DNA damage
por: Park, Caroline, et al.
Publicado: (2015)

Clinical relevance of blood-based ctDNA analysis: mutation detection and beyond
por: Keller, Laura, et al.
Publicado: (2020)

Role for the Mammalian Swi5-Sfr1 Complex in DNA Strand Break Repair through Homologous Recombination
por: Akamatsu, Yufuko, et al.
Publicado: (2010)

Activation of mammalian Chk1 during DNA replication arrest: a role for Chk1 in the intra-S phase checkpoint monitoring replication origin firing
por: Feijoo, Carmen, et al.
Publicado: (2001)

Second-Generation Antiandrogen Therapy Radiosensitizes Prostate Cancer Regardless of Castration State through Inhibition of DNA Double Strand Break Repair
por: Elsesy, Mohamed E., et al.
Publicado: (2020)

Structure-Specific DNA Endonuclease Mus81/Eme1 Generates DNA Damage Caused by Chk1 Inactivation
por: Forment, Josep V., et al.
Publicado: (2011)

Co-Inhibition of the DNA Damage Response and CHK1 Enhances Apoptosis of Neuroblastoma Cells
por: Ando, Kiyohiro, et al.
Publicado: (2019)

Structural basis for recruitment of the CHK1 DNA damage kinase by the CLASPIN scaffold protein
por: Day, Matthew, et al.
Publicado: (2021)

Analyzing the influence of kinase inhibitors on DNA repair by differential proteomics of chromatin-interacting proteins and nuclear phospho-proteins
por: Gleißner, Lisa, et al.
Publicado: (2017)

EZH2 activates CHK1 signaling to promote ovarian cancer chemoresistance by maintaining the properties of cancer stem cells
por: Wen, Yiping, et al.
Publicado: (2021)

Establishment of a Transformation Coupled in vitro End Joining Assay to Estimate Radiosensitivity in Tumor Cells
por: Degenhardt, Sarah, et al.
Publicado: (2020)

Early Chk1 Phosphorylation Is Driven by Temozolomide-Induced, DNA Double Strand Break- and Mismatch Repair-Independent DNA Damage
por: Ito, Motokazu, et al.
Publicado: (2013)

Clinical applications and utility of cell-free DNA-based liquid biopsy analyses in cervical cancer and its precursor lesions
por: Herbst, Johanna, et al.
Publicado: (2022)

Multiple ATR-Chk1 Pathway Proteins Preferentially Associate with Checkpoint-Inducing DNA Substrates
por: Yilmaz, Seçil, et al.
Publicado: (2011)

Chk1 and Wee1 kinases coordinate DNA replication, chromosome condensation, and anaphase entry
por: Fasulo, Barbara, et al.
Publicado: (2012)

Phosphorylation-Dependent Interactions between Crb2 and Chk1 Are Essential for DNA Damage Checkpoint
por: Qu, Meng, et al.
Publicado: (2012)

DNA-PKcs is required to maintain stability of Chk1 and Claspin for optimal replication stress response
por: Lin, Yu-Fen, et al.
Publicado: (2014)

KA1-targeted regulatory domain mutations activate Chk1 in the absence of DNA damage
por: Gong, Eun-Yeung, et al.
Publicado: (2015)

Chk2 and REGγ-dependent DBC1 regulation in DNA damage induced apoptosis
por: Magni, Martina, et al.
Publicado: (2014)

Modification of tumour cell metabolism modulates sensitivity to Chk1 inhibitor-induced DNA damage
por: Massey, Andrew J.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_g5u35qvsk6m60v8b7gu9sh4n3t