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Allometric Scaling Approaches for Predicting Human Pharmacokinetic of a Locked Nucleic Acid Oligonucleotide Targeting Cancer-Associated miR-221

LNA-i-miR-221 is a novel phosphorothioate backbone 13-mer locked nucleic acid oligonucleotide-targeting microRNA-221 designed for the treatment of human malignancies. To understand the pharmacokinetic properties of this new agent, including unbound/total clearance, we investigated the LNA-i-miR-221...

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Detalles Bibliográficos
Autores principales:	Di Martino, Maria Teresa, Arbitrio, Mariamena, Fonsi, Massimiliano, Erratico, Claudio Alberto, Scionti, Francesca, Caracciolo, Daniele, Tagliaferri, Pierosandro, Tassone, Pierfrancesco
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7017297/ https://www.ncbi.nlm.nih.gov/pubmed/31861748 http://dx.doi.org/10.3390/cancers12010027

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